Literature DB >> 18183536

Methylnaltrexone, a new peripheral mu-receptor antagonist for the prevention and treatment of opioid-induced extracerebral side effects.

Florian M Reichle1, Peter F Conzen.   

Abstract

Progenics Pharmaceuticals Inc and Wyeth Pharmaceuticals are developing methylnaltrexone, a micro-receptor opioid antagonist derived from naltrexone by the addition of a methyl group. The intravenous formulation of methylnaltrexone is currently in phase III clinical trials for the potential treatment of postoperative ileus.

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Year:  2008        PMID： 18183536

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  7 in total

Review 1.  Management of opioid-induced constipation in cancer patients: focus on methylnaltrexone.

Authors:  Antonio Gatti; Alessandro Fabrizio Sabato
Journal:  Clin Drug Investig       Date:  2012-05-01       Impact factor: 2.859

2.  Managing opioid-induced constipation in advanced illness: focus on methylnaltrexone bromide.

Authors:  Katri Elina Clemens; Eberhard Klaschik
Journal:  Ther Clin Risk Manag       Date:  2010-03-03       Impact factor: 2.423

3.  Methylnaltrexone: the evidence for its use in the management of opioid-induced constipation.

Authors:  Peter Deibert; Carola Xander; Hubert E Blum; Gerhild Becker
Journal:  Core Evid       Date:  2010-06-15

Review 4.  Opioid receptors in the gastrointestinal tract.

Authors:  Peter Holzer
Journal:  Regul Pept       Date:  2009-04-02

5.  Effects of methylnaltrexone on guinea pig gastrointestinal motility.

Authors:  Laura Anselmi; Jennifer Huynh; Gaia Vegezzi; Catia Sternini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-01-30       Impact factor: 3.000

6.  Incidence and Health Related Quality of Life of Opioid-Induced Constipation in Chronic Noncancer Pain Patients: A Prospective Multicentre Cohort Study.

Authors:  Dalila R Veiga; Liliane Mendonça; Rute Sampaio; José C Lopes; Luís F Azevedo
Journal:  Pain Res Treat       Date:  2018-07-10

Review 7.  New approaches to the treatment of opioid-induced constipation.

Authors:  P Holzer
Journal:  Eur Rev Med Pharmacol Sci       Date:  2008-08       Impact factor: 3.507
  7 in total

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