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Literature DB >> 18182288

Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.

Mohammad Amir¹, Harish Kumar, Suroor A Khan.

Abstract

A series of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (2a-h) and 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (3a-h) were synthesized by condensation of chalcones with hydrazine hydrate in solvent system ethanol and DMF. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activity, and were compared with standard drug. Among the compounds studied, compound 2e showed more potent anti-inflammatory and analgesic activity than the standard drug, along with minimum ulcerogenic index.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18182288 DOI： 10.1016/j.bmcl.2007.12.043

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

29 in total

1. The synthesis, X-ray crystal structure and optical properties of novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline derivatives.

Authors: Zhong-Liang Gong; Yong-Sheng Xie; Bao-Xiang Zhao; Hong-Shui Lv; Wei-Yong Liu; Liang-Wen Zheng; Song Lian
Journal: J Fluoresc Date: 2010-10-02 Impact factor: 2.217

2. Molecular docking and pharmacological/toxicological assessment of a new compound designed from celecoxib and paracetamol by molecular hybridization.

Authors: Daiany P B da Silva; Iziara F Florentino; Dayane M da Silva; Roberta C Lino; Carina S Cardoso; Lorrane K S Moreira; Géssica A Vasconcelos; Daniela C Vinhal; Anna C D Cardoso; Bianca Villavicencio; Hugo Verli; Boniek G Vaz; Luciano M Lião; Luiz C da Cunha; Ricardo Menegatti; Elson A Costa
Journal: Inflammopharmacology Date: 2018-07-23 Impact factor: 4.473

Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.

1. The synthesis, X-ray crystal structure and optical properties of novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline derivatives.

2. Molecular docking and pharmacological/toxicological assessment of a new compound designed from celecoxib and paracetamol by molecular hybridization.

Review 3. A Comprehensive Review of Aminochalcones.

4. 1-[3,5-Bis(4-fluoro-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

5. 3-Chloro-6-{4-[3-(trifluoro-meth-yl)phen-yl]piperazin-1-yl}pyridazine.

6. 3,5-Bis(4-bromo-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

7. 3-[5-(2,4-Dichloro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-hy-droxy-2H-chromen-2-one.

8. 3,5-Bis(4-fluoro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

9. 2-[1-(9-Anthrylmeth-yl)-1H-pyrazol-3-yl]pyridine.

10. 3,5-Bis(4-meth-oxy-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.