Literature DB >> 18182246

Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide.

Katsutoshi Yayama1, Hiroshi Okamoto.   

Abstract

Angiotensin II (Ang II) plays important roles in the regulation of cardiovascular functions and diseases mainly via the type 1 (AT1) receptor. In contrast, recent studies have shown that the actions of Ang II via the type 2 (AT2) receptor are counter-regulatory to those mediated via the AT1 receptor. Using an animal model of hypertension, we have demonstrated that Ang II produces a vasodilator effect through the AT2 receptor via the bradykinin (BK)-dependent activation of endothelial nitric oxide (NO) synthase. In this review, we focus on the role of BK and NO in AT2-receptor-mediated vasodilation.

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Year:  2007        PMID： 18182246     DOI： 10.1016/j.intimp.2007.06.012

Source DB:  PubMed          Journal:  Int Immunopharmacol        ISSN： 1567-5769            Impact factor:   4.932


  32 in total

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9.  Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension.

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