Literature DB >> 18181946

The importance of valid disclosures in the human embryonic stem cell research debate.

J L Sherley1.   

Abstract

Misinformation erodes the legitimacy of any public debate. Since the start of human embryonic stem cell research deliberations in the USA, misinformation concerning the nature of human embryos, their availability for research, and the potential for using them to develop new medical therapies have been widespread and persistent. Basic facts, well understood by physicians and biologists, have been so misstated and misrepresented in the news media and political speeches that the general public has been put in a state of constant uncertainty. The solution to the present troubling condition is better education in the form of diligent, honest, and complete scientific disclosure by responsible scientists and physicians; and more care given to accurate reporting by news media. Several key aspects of newly emerging embryonic and non-embryonic stem cell technologies are defined and discussed as they relate to the debate over the use of human embryos for medical research. An important topic for consideration is how to disclose with clarity the scientific basis for human embryonic life. Thereafter, failings in proposed technologies for developing new therapies with human embryonic stem cells, that have been grossly under-reported, are examined. Finally, properties of adult stem cells are presented in contradistinction to embryonic stem cells, both in terms of adult stem cells as a scientifically better alternative to embryonic stem cells and in terms of the technological challenges that must be overcome to realize the potential of adult stem cells for new medical therapies.

Entities:  

Mesh:

Year:  2008        PMID: 18181946      PMCID: PMC6496409          DOI: 10.1111/j.1365-2184.2008.00483.x

Source DB:  PubMed          Journal:  Cell Prolif        ISSN: 0960-7722            Impact factor:   6.831


  12 in total

Review 1.  Asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture.

Authors:  James L Sherley
Journal:  Stem Cells       Date:  2002       Impact factor: 6.277

2.  Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds.

Authors:  Carlos E Semino; Joshua R Merok; Gracy G Crane; Georgia Panagiotakos; Shuguang Zhang
Journal:  Differentiation       Date:  2003-06       Impact factor: 3.880

3.  Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells.

Authors:  Lakshmi Rambhatla; Sumati Ram-Mohan; Jennifer J Cheng; James L Sherley
Journal:  Cancer Res       Date:  2005-04-15       Impact factor: 12.701

4.  Human embryonic stem cell lines derived from single blastomeres.

Authors:  Irina Klimanskaya; Young Chung; Sandy Becker; Shi-Jiang Lu; Robert Lanza
Journal:  Nature       Date:  2006-08-23       Impact factor: 49.962

5.  Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts.

Authors:  Steven J McArthur; Don Leigh; James T Marshall; Kylie A de Boer; Robert P S Jansen
Journal:  Fertil Steril       Date:  2005-12       Impact factor: 7.329

6.  EMP-1 is a junctional protein in a liver stem cell line and in the liver.

Authors:  Hsuan-Shu Lee; James L Sherley; Jeremy J W Chen; Chien-Chang Chiu; Ling-Ling Chiou; Ja-Der Liang; Pan-Chyr Yang; Guan-Tarn Huang; Jin-Chuan Sheu
Journal:  Biochem Biophys Res Commun       Date:  2005-09-09       Impact factor: 3.575

7.  Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK).

Authors:  Hsuan-Shu Lee; Gracy G Crane; Joshua R Merok; James R Tunstead; Nicole L Hatch; Krishnanchali Panchalingam; Mark J Powers; Linda G Griffith; James L Sherley
Journal:  Biotechnol Bioeng       Date:  2003-09-30       Impact factor: 4.530

8.  Cellular Senescence: Ex Vivo p53-Dependent Asymmetric Cell Kinetics.

Authors:  Lakshmi Rambhatla; Shirley A. Bohn; Patrizia B. Stadler; Jonathan T. Boyd; Ronald A. Coss; James L. Sherley
Journal:  J Biomed Biotechnol       Date:  2001

9.  Breaching the Kinetic Barrier to In Vitro Somatic Stem Cell Propagation.

Authors:  Joshua R. Merok; James L. Sherley
Journal:  J Biomed Biotechnol       Date:  2001

10.  Human Embryonic Stem Cell Research: No Way Around a Scientific Bottleneck.

Authors:  James L. Sherley
Journal:  J Biomed Biotechnol       Date:  2004
View more
  1 in total

1.  'Not taken in by media hype': how potential donors, recipients and members of the general public perceive stem cell research.

Authors:  V L Peddie; M Porter; C Counsell; L Caie; D Pearson; S Bhattacharya
Journal:  Hum Reprod       Date:  2009-01-24       Impact factor: 6.918

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.