Literature DB >> 1818187

Binding of 125I-labelled tumor necrosis factor to Pneumocystis carinii and an insoluble cell wall fraction.

E L Pesanti1, T Tomicic, S T Donta.   

Abstract

We have previously shown that tumor necrosis factor-alpha (TNF-alpha) causes loss of viability of Pneumocystis carinii. In this study, we demonstrate that TNF-alpha irreversibly binds to P. carinii in vitro. The avidity of binding is orders of magnitude greater than that by which it binds to a known sensitive target, L929 cells. A detergent-insoluble fraction of P. carinii, which consists primarily of cyst walls, bound ten times more TNF-alpha per microgram protein as did whole P. carinii.

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Year:  1991        PMID： 1818187

Source DB:  PubMed          Journal:  J Protozool        ISSN： 0022-3921


  4 in total

1.  Pneumocystis carinii inhibits cyclin-dependent kinase activity in lung epithelial cells.

Authors:  A H Limper; M Edens; R A Anders; E B Leof
Journal:  J Clin Invest       Date:  1998-03-01       Impact factor: 14.808

2.  The role of alveolar macrophages in Pneumocystis carinii degradation and clearance from the lung.

Authors:  A H Limper; J S Hoyte; J E Standing
Journal:  J Clin Invest       Date:  1997-05-01       Impact factor: 14.808

3.  Fungal beta-glucan interacts with vitronectin and stimulates tumor necrosis factor alpha release from macrophages.

Authors:  E J Olson; J E Standing; N Griego-Harper; O A Hoffman; A H Limper
Journal:  Infect Immun       Date:  1996-09       Impact factor: 3.441

4.  Steady-state effects of vitronectin and fibronectin on the binding, uptake, and degradation of Pneumocystis carinii in rat alveolar macrophages.

Authors:  J S Hoyte; J E Standing; A H Limper
Journal:  Inflammation       Date:  1997-06       Impact factor: 4.092
  4 in total

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