Literature DB >> 1818184

Cytokine- and Pneumocystis carinii- induced L-arginine oxidation by murine and human pulmonary alveolar macrophages.

M P Sherman1, M L Loro, V Z Wong, D P Tashkin.   

Abstract

Lipopolysaccharide plus interferon gamma stimulated the L-arginine-.NO pathway of murine, but not human pulmonary alveolar macrophages. Pneumocystis carinii induced .NO production by both murine and human pulmonary alveolar macrophages suggesting that the parasite stimulates L-arginine oxidation in these cells. The potential anti-Pneumocystis activity of .NO warrants further study.

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Year:  1991        PMID： 1818184

Source DB:  PubMed          Journal:  J Protozool        ISSN： 0022-3921


  15 in total

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