Literature DB >> 18181638

Proteolytic activity of Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane.

Seung Woo Jang1, Junghun Suh.   

Abstract

Proteolytic activity of the Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane (oxacyclen) was compared with that of the Cu(II) complex of 1,4,7,10-tetraazacyclododecane by using albumin, gamma-globulin, and myoglobin as substrates. Values of kcat/Km were greater for Cu(II)oxacyclen by 40-80 times. The enhanced activity is attributed to the increased Lewis acidity of Cu(II) due to substitution of one nitrogen donor atom with oxygen.

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Year:  2008        PMID： 18181638     DOI： 10.1021/ol702860h

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Soluble artificial metalloproteases with broad substrate selectivity, high reactivity, and high thermal and chemical stabilities.

Authors:  Min Gyum Kim; Sang Ho Yoo; Woo Suk Chei; Tae Yeon Lee; Hye Mi Kim; Junghun Suh
Journal:  J Biol Inorg Chem       Date:  2010-04-28       Impact factor: 3.358

2.  Proteolytic activity of Co(III) complex of 1-oxa-4,7,10-triazacyclododecane: a new catalytic center for peptide-cleavage agents.

Authors:  Hye Mi Kim; Boonjae Jang; Young Eun Cheon; Myunghyun Paik Suh; Junghun Suh
Journal:  J Biol Inorg Chem       Date:  2008-10-05       Impact factor: 3.358

3.  MOFzyme: Intrinsic protease-like activity of Cu-MOF.

Authors:  Bin Li; Daomei Chen; Jiaqiang Wang; Zhiying Yan; Liang Jiang; Jiao He; Zhongrui Luo; Jinping Zhang; Fagui Yuan
Journal:  Sci Rep       Date:  2014-10-24       Impact factor: 4.379
  3 in total

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