Literature DB >> 1818068

Determination of 9-[(2-phosphonylmethoxy)ethyl]adenine in rat urine by high-performance liquid chromatography with fluorescence detection.

J W Russell1, D Marrero, V J Whiterock, L J Klunk, J E Starrett.   

Abstract

A high-performance liquid chromatographic (HPLC) method for the determination of 9-[(2-phosphonylmethoxy)ethyl]adenine (PMEA) in urine is described. The procedure includes treatment of the urine sample with chloroacetaldehyde to form the fluorescent 1,N6-ethenoadenosine derivative, which was analyzed by reversed-phase HPLC with fluorometric detection. Validation of the method showed good sensitivity, precision and reproducibility. The method is useful for the study of urinary excretion of PMEA in the rat.

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Year:  1991        PMID： 1818068     DOI： 10.1016/0378-4347(91)80498-2

Source DB:  PubMed          Journal:  J Chromatogr


  7 in total

Review 1.  Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir.

Authors:  K C Cundy
Journal:  Clin Pharmacokinet       Date:  1999-02       Impact factor: 6.447

2.  Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.

Authors:  L Naesens; J Balzarini; N Bischofberger; E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1996-01       Impact factor: 5.191

3.  Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.

Authors:  J P Shaw; C M Sueoko; R Oliyai; W A Lee; M N Arimilli; C U Kim; K C Cundy
Journal:  Pharm Res       Date:  1997-12       Impact factor: 4.200

4.  Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection: a pilot study.

Authors:  S Arends; E van Halteren; W Kamp; J Schokker
Journal:  Pharm World Sci       Date:  1996-01

5.  Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys.

Authors:  K C Cundy; J P Shaw; W A Lee
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

6.  Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients.

Authors:  K C Cundy; P Barditch-Crovo; R E Walker; A C Collier; D Ebeling; J Toole; H S Jaffe
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

7.  Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys.

Authors:  K C Cundy; J A Fishback; J P Shaw; M L Lee; K F Soike; G C Visor; W A Lee
Journal:  Pharm Res       Date:  1994-06       Impact factor: 4.200
  7 in total

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