Literature DB >> 18180346

Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America.

Roseanne A Ressner1, Matthew R Moore, James H Jorgensen.   

Abstract

Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active, with a MIC 50 of 0.25 microg/ml, a MIC 90 of 0.5 microg/ml, and a range of <or=0.008 microg/ml to 1 microg/ml.

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Year:  2008        PMID： 18180346      PMCID： PMC2258536          DOI： 10.1128/AAC.01387-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Diversity and antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae carriage isolates in the post-heptavalent conjugate vaccine era.

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Journal:  J Infect Dis       Date:  2006-12-27       Impact factor: 5.226

2.  Increased antimicrobial resistance among nonvaccine serotypes of Streptococcus pneumoniae in the pediatric population after the introduction of 7-valent pneumococcal vaccine in the United States.

Authors:  David J Farrell; Keith P Klugman; Michael Pichichero
Journal:  Pediatr Infect Dis J       Date:  2007-02       Impact factor: 2.129

3.  Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae.

Authors:  Moe H Kyaw; Ruth Lynfield; William Schaffner; Allen S Craig; James Hadler; Arthur Reingold; Ann R Thomas; Lee H Harrison; Nancy M Bennett; Monica M Farley; Richard R Facklam; James H Jorgensen; John Besser; Elizabeth R Zell; Anne Schuchat; Cynthia G Whitney
Journal:  N Engl J Med       Date:  2006-04-06       Impact factor: 91.245

4.  Postvaccine genetic structure of Streptococcus pneumoniae serotype 19A from children in the United States.

Authors:  Rekha Pai; Matthew R Moore; Tamara Pilishvili; Robert E Gertz; Cynthia G Whitney; Bernard Beall
Journal:  J Infect Dis       Date:  2005-11-01       Impact factor: 5.226

5.  Antimicrobial resistance among Streptococcus pneumoniae in the United States: have we begun to turn the corner on resistance to certain antimicrobial classes?

Authors:  Gary V Doern; Sandra S Richter; Ashley Miller; Norma Miller; Cassie Rice; Kristopher Heilmann; Susan Beekmann
Journal:  Clin Infect Dis       Date:  2005-06-07       Impact factor: 9.079

6.  An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome.

Authors:  Victor L Yu; Christine C C Chiou; Charles Feldman; Ake Ortqvist; Jordi Rello; Arthur J Morris; Larry M Baddour; Carlos M Luna; David R Snydman; Margaret Ip; Wen Chien Ko; M Bernadete F Chedid; Antoine Andremont; Keith P Klugman
Journal:  Clin Infect Dis       Date:  2003-07-07       Impact factor: 9.079

Review 7.  A review of clinical failures associated with macrolide-resistant Streptococcus pneumoniae.

Authors:  Marek Rzeszutek; Aleksandra Wierzbowski; Daryl J Hoban; John Conly; William Bishai; George G Zhanel
Journal:  Int J Antimicrob Agents       Date:  2004-08       Impact factor: 5.283

8.  Risk factors and response to antibiotic therapy in adults with bacteremic pneumonia caused by penicillin-resistant pneumococci.

Authors:  R Pallares; F Gudiol; J Liñares; J Ariza; G Rufi; L Murgui; J Dorca; P F Viladrich
Journal:  N Engl J Med       Date:  1987-07-02       Impact factor: 91.245

Review 9.  Management of infections due to antibiotic-resistant Streptococcus pneumoniae.

Authors:  S L Kaplan; E O Mason
Journal:  Clin Microbiol Rev       Date:  1998-10       Impact factor: 26.132

Review 10.  Hidden epidemic of macrolide-resistant pneumococci.

Authors:  Keith P Klugman; John R Lonks
Journal:  Emerg Infect Dis       Date:  2005-06       Impact factor: 6.883
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  1 in total

1.  A microdose study of ¹⁴C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung.

Authors:  G Lappin; M J Boyce; T Matzow; S Lociuro; M Seymour; S J Warrington
Journal:  Eur J Clin Pharmacol       Date:  2013-06-06       Impact factor: 2.953
  1 in total

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