| Literature DB >> 18180147 |
Marta Martins1, Sujata G Dastidar, Seamus Fanning, Jette E Kristiansen, Joseph Molnar, Jean-Marie Pagès, Zsuzsanna Schelz, Gabriella Spengler, Miguel Viveiros, Leonard Amaral.
Abstract
Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.Entities:
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Year: 2008 PMID： 18180147 DOI： 10.1016/j.ijantimicag.2007.10.025
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283