| Literature DB >> 18180033 |
Meilani Syampurnawati1, Eiji Tatsumi, Bambang Ardianto, Mariko Takenokuchi, Yuji Nakamachi, Seiji Kawano, Shun-ichi Kumagai, Katsuyasu Saigo, Toshimitsu Matsui, Takayuki Takahashi, Ken-ichi Nagai, Hisahide Nishio, Hiroki Yabe, Shin-Ichi Kondo, Yoshitake Hayashi.
Abstract
Our previous observation of a higher incidence of FLT3-ITD in DR(-) M1/M2 AML than in DR(+) M1/M2 led to an investigation of NPM1 mutation in the same samples, since DR(-) AML and AML with NPM1 mutation share such characteristics as normal karyotype, the absence of CD34, and FLT3-ITD. NPM1 mutation was found in 18 of 26 (69.2%) of DR(-) cases, but not in any of 28 DR(+) cases. FLT3-ITD was noted in 66.7% of the cases with NPM1 mutation. These findings point to DR negativity as another phenotypic feature of AML with NPM1 mutation.Entities:
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Year: 2008 PMID： 18180033 DOI： 10.1016/j.leukres.2007.11.017
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156