| Literature DB >> 18179388 |
Jean K Lim1, Christine Y Louie, Carol Glaser, Cynthia Jean, Bernard Johnson, Hope Johnson, David H McDermott, Philip M Murphy.
Abstract
West Nile virus (WNV) causes disease in approximately 20% of infected humans. We previously reported that homozygosity for CCR5Delta32, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, odds ratio [OR], 4.2 [95% confidence interval {CI}, 1.5-11.9] [P= .004]; for Illinois, OR, 3.1 [95% CI, 0.9-11.2] [P= .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P= .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States.Entities:
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Year: 2008 PMID： 18179388 DOI： 10.1086/524691
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226