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Literature DB >> 18178792

Are two better than one? Angiotensin-converting enzyme inhibitors plus angiotensin receptor blockers for reducing blood pressure and proteinuria in kidney disease.

Abstract

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers each reduce proteinuria and blood pressure. Several studies have compared the antiproteinuric and antihypertensive effects of combination therapy with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with those of therapy with either drug class alone. This article reviews those trials as well as evidence suggesting a mechanism for the benefits observed with combination therapy.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18178792 PMCID： PMC3152269 DOI： 10.2215/CJN.03270807

Source DB: PubMed Journal: Clin J Am Soc Nephrol ISSN： 1555-9041 Impact factor: 8.237

19 in total

1. Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy.

Authors: D Russo; R Minutolo; A Pisani; R Esposito; G Signoriello; M Andreucci; M M Balletta
Journal: Am J Kidney Dis Date: 2001-07 Impact factor: 8.860

2. Dual blockade of the renin-angiotensin system versus maximal recommended dose of ACE inhibition in diabetic nephropathy.

Authors: Peter Jacobsen; Steen Andersen; Kasper Rossing; Berit R Jensen; Hans-Henrik Parving
Journal: Kidney Int Date: 2003-05 Impact factor: 10.612

3. Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study.

Authors: C E Mogensen; S Neldam; I Tikkanen; S Oren; R Viskoper; R W Watts; M E Cooper
Journal: BMJ Date: 2000-12-09

4. Additive effect of ACE inhibition and angiotensin II receptor blockade in type I diabetic patients with diabetic nephropathy.

Authors: Peter Jacobsen; Steen Andersen; Berit R Jensen; Hans-Henrik Parving
Journal: J Am Soc Nephrol Date: 2003-04 Impact factor: 10.121

5. Add-on angiotensin receptor blockade with maximized ACE inhibition.

Authors: R Agarwal
Journal: Kidney Int Date: 2001-06 Impact factor: 10.612

6. Lesser response to angiotensin-converting-enzyme inhibitor therapy in black as compared with white patients with left ventricular dysfunction.

Authors: D V Exner; D L Dries; M J Domanski; J N Cohn
Journal: N Engl J Med Date: 2001-05-03 Impact factor: 91.245

7. Dual renin-angiotensin system blockade at optimal doses for proteinuria.

Authors: Gozewijn D Laverman; Gerjan Navis; Robert H Henning; Paul E de Jong; Dick de Zeeuw
Journal: Kidney Int Date: 2002-09 Impact factor: 10.612

8. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial.

Authors: Naoyuki Nakao; Ashio Yoshimura; Hiroyuki Morita; Masyuki Takada; Tsuguo Kayano; Terukuni Ideura
Journal: Lancet Date: 2003-01-11 Impact factor: 79.321