OBJECTIVE: Surrogate serum markers of cholesterol synthesis (e.g. squalene, lathosterol) and absorption (e.g. cholestanol, campesterol) were studied in adolescent boys to show whether homeostasis of cholesterol metabolism is maintained in different age cohorts and within different absorption levels. STUDY POPULATION AND METHODS: In random population samples of 12- (n=162), 15- (n=158), and 18- (n=148) year-old boys participating in Cardiovascular Risk in Young Finns Study serum sterols and squalene were measured with gas-liquid chromatography at baseline, and expressed as ratios to cholesterol. Quartiles of cholestanol indicating low to high cholesterol absorption were defined from whole population. RESULTS: Age-dependent decrease of serum cholesterol was associated with increased synthesis and decreased absorption of cholesterol (e.g. campesterol 205+/-6 vs. 176+/-4 in 12- vs. 18-year-old, p<0.05). In whole population, synthesis and absorption markers were interrelated indicating maintenance of homeostasis of cholesterol metabolism. Synthesis markers decreased and those of absorption increased linearly from first (low absorption) to fourth cholestanol quartile (high absorption). Correlation between synthesis and absorption, however, was significant in the lowest quartile only (lathosterol vs. campesterol, quartile 1, r=-0.283, p<0.05; quartile 4, r=-0.070, NS). CONCLUSIONS: Even though cholesterol absorption and synthesis are usually changed in opposite directions, in cases with high absorption the maintenance of homeostasis of cholesterol metabolism can be lost, so that synthesis and absorption of cholesterol are changed independently of each other.
OBJECTIVE: Surrogate serum markers of cholesterol synthesis (e.g. squalene, lathosterol) and absorption (e.g. cholestanol, campesterol) were studied in adolescent boys to show whether homeostasis of cholesterol metabolism is maintained in different age cohorts and within different absorption levels. STUDY POPULATION AND METHODS: In random population samples of 12- (n=162), 15- (n=158), and 18- (n=148) year-old boys participating in Cardiovascular Risk in Young Finns Study serum sterols and squalene were measured with gas-liquid chromatography at baseline, and expressed as ratios to cholesterol. Quartiles of cholestanol indicating low to high cholesterol absorption were defined from whole population. RESULTS: Age-dependent decrease of serum cholesterol was associated with increased synthesis and decreased absorption of cholesterol (e.g. campesterol 205+/-6 vs. 176+/-4 in 12- vs. 18-year-old, p<0.05). In whole population, synthesis and absorption markers were interrelated indicating maintenance of homeostasis of cholesterol metabolism. Synthesis markers decreased and those of absorption increased linearly from first (low absorption) to fourth cholestanol quartile (high absorption). Correlation between synthesis and absorption, however, was significant in the lowest quartile only (lathosterol vs. campesterol, quartile 1, r=-0.283, p<0.05; quartile 4, r=-0.070, NS). CONCLUSIONS: Even though cholesterol absorption and synthesis are usually changed in opposite directions, in cases with high absorption the maintenance of homeostasis of cholesterol metabolism can be lost, so that synthesis and absorption of cholesterol are changed independently of each other.
Authors: Helena E Miettinen; Kristiina Rönö; Saila Koivusalo; Beata Stach-Lempinen; Maritta Pöyhönen-Alho; Johan G Eriksson; Timo P Hiltunen; Helena Gylling Journal: J Lipid Res Date: 2014-10-09 Impact factor: 5.922
Authors: Valéria Sutti Nunes; Edite Vieira Silva de Campos; Jamal Baracat; Victor França; Érica Ivana Lázaro Gomes; Raissa Peres Coelho; Edna Regina Nakandakare; Vanessa Helena Souza Zago; Eliana Cotta de Faria; Eder Carlos Rocha Quintão Journal: Int J Mol Sci Date: 2022-10-09 Impact factor: 6.208
Authors: Monica Gelzo; Maria Donata Di Taranto; Concetta Sica; Antonio Boscia; Francesco Papagni; Giuliana Fortunato; Gaetano Corso; Antonio Dello Russo Journal: Lipids Health Dis Date: 2019-12-30 Impact factor: 3.876