OBJECTIVE: To evaluate whether single nucleotide FSH receptor and DAZL gene polymorphisms are associated with menarche and menopause timing. DESIGN: Prospective study. SETTING: Siena and Münster Universities. PATIENT(S): Physiologically menopausal women. INTERVENTION(S): The presence of FSH receptor or DAZL gene polymorphisms was investigated. Blood samples were collected and polymorphisms evaluated in extracted genomic DNA. MAIN OUTCOME MEASURE(S): Menarche age, menopausal age, and total years of fertility were evaluated on the basis of FSH receptor (genotypes Asn/Asn, Asn/Ser, and Ser/Ser at codon 680) and DAZL gene. RESULT(S): The median age of menarche was 13 years in the Asn/Asn group and 12 years in the Asn/Ser and Ser/Ser groups. The median age at menopause was 50 years in the Asn/Asn and Asn/Ser groups and 51 years in the Ser/Ser group. The length of the fertile period was 37 years in the Asn/Asn group, 38 years in the Asn/Ser group, and 39 years in the Ser/Ser group. Regarding the DAZL polymorphism, A/A, A/G, and G/G had the same age at menarche, age at menopause, and length of fertile period. CONCLUSION(S): We found that genotype of FSH receptor or SNP of DAZL do not predict the age at natural menopause and duration of fertility in women. The presence of Asn680/Asn680 genotype is associated with a slightly delayed age at menarche.
OBJECTIVE: To evaluate whether single nucleotide FSH receptor and DAZL gene polymorphisms are associated with menarche and menopause timing. DESIGN: Prospective study. SETTING: Siena and Münster Universities. PATIENT(S): Physiologically menopausal women. INTERVENTION(S): The presence of FSH receptor or DAZL gene polymorphisms was investigated. Blood samples were collected and polymorphisms evaluated in extracted genomic DNA. MAIN OUTCOME MEASURE(S): Menarche age, menopausal age, and total years of fertility were evaluated on the basis of FSH receptor (genotypes Asn/Asn, Asn/Ser, and Ser/Ser at codon 680) and DAZL gene. RESULT(S): The median age of menarche was 13 years in the Asn/Asn group and 12 years in the Asn/Ser and Ser/Ser groups. The median age at menopause was 50 years in the Asn/Asn and Asn/Ser groups and 51 years in the Ser/Ser group. The length of the fertile period was 37 years in the Asn/Asn group, 38 years in the Asn/Ser group, and 39 years in the Ser/Ser group. Regarding the DAZL polymorphism, A/A, A/G, and G/G had the same age at menarche, age at menopause, and length of fertile period. CONCLUSION(S): We found that genotype of FSH receptor or SNP of DAZL do not predict the age at natural menopause and duration of fertility in women. The presence of Asn680/Asn680 genotype is associated with a slightly delayed age at menarche.
Authors: A F Nabhan; G Mburu; F Elshafeey; R Magdi; M Kamel; M Elshebiny; Y G Abuelnaga; M Ghonim; M H Abdelhamid; Mo Ghonim; P Eid; A Morsy; M Nasser; N Abdelwahab; F Elhayatmy; A A Hussein; N Elgabaly; E Sawires; Y Tarkhan; Y Doas; N Farrag; A Amir; M F Gobran; M Maged; M Abdulhady; Y Sherif; M Dyab; J Kiarie Journal: Hum Reprod Open Date: 2022-02-11
Authors: Roseanne Rosario; James H Crichton; Hazel L Stewart; Andrew J Childs; Ian R Adams; Richard A Anderson Journal: FASEB J Date: 2019-10-26 Impact factor: 5.834