OBJECTIVE: To study serum and follicular fluid (FF) hormone levels after the administration of urinary or recombinant hCG to initiate the final stages of oocyte maturation during IVF. DESIGN: Prospective randomized study between 250 microg of recombinant hCG and 7,500 IU of urinary hCG as the final trigger of ovulation during IVF. SETTING: Private IVF center. PATIENT(S): Infertile women undergoingIVF/intracytoplasmic sperm injection (ICSI) using the long protocol and recombinant FSH. INTERVENTION(S): IVF treatment. Serum and FF hormone measurements on the day of oocyte collection. MAIN OUTCOME MEASURE(S): Serum and FF E(2), P, hCG, and T levels. RESULT(S): Stimulation parameters, serum and follicular E(2), P, T, and hCG levels were similar in the recombinant and urinary hCG groups. The number of oocytes retrieved from follicles >14 mm, the proportion of mature oocytes, fertilization rate, and pregnancy rate (PR) were also comparable. CONCLUSION(S): Recombinant and urinary hCG provided similar serum and follicular hormonal environments during the final stages of oocyte maturation. The IVF outcome parameters were also comparable. The two medications appear to be equally effective.
RCT Entities:
OBJECTIVE: To study serum and follicular fluid (FF) hormone levels after the administration of urinary or recombinant hCG to initiate the final stages of oocyte maturation during IVF. DESIGN: Prospective randomized study between 250 microg of recombinant hCG and 7,500 IU of urinary hCG as the final trigger of ovulation during IVF. SETTING: Private IVF center. PATIENT(S): Infertile women undergoing IVF/intracytoplasmic sperm injection (ICSI) using the long protocol and recombinant FSH. INTERVENTION(S): IVF treatment. Serum and FF hormone measurements on the day of oocyte collection. MAIN OUTCOME MEASURE(S): Serum and FF E(2), P, hCG, and T levels. RESULT(S): Stimulation parameters, serum and follicular E(2), P, T, and hCG levels were similar in the recombinant and urinary hCG groups. The number of oocytes retrieved from follicles >14 mm, the proportion of mature oocytes, fertilization rate, and pregnancy rate (PR) were also comparable. CONCLUSION(S): Recombinant and urinary hCG provided similar serum and follicular hormonal environments during the final stages of oocyte maturation. The IVF outcome parameters were also comparable. The two medications appear to be equally effective.
Authors: József Zeke; Katalin Kanyó; Helga Zeke; Aron Cseh; Barna Vásárhelyi; András Szilágyi; János Konc Journal: ScientificWorldJournal Date: 2011-10-19
Authors: Frank Vandekerckhove; Jan Gerris; Stijn Vansteelandt; An De Baerdemaeker; Kelly Tilleman; Petra De Sutter Journal: Reprod Biol Endocrinol Date: 2014-04-23 Impact factor: 5.211