| Literature DB >> 18177719 |
Matthew J Watt1, Andrea L Hevener.
Abstract
Elevated fatty acids promote inflammation and insulin resistance. In this issue of Cell Metabolism, Koves et al. (2008) explore a novel paradigm suggesting that beta-oxidation of fatty acids exceeding the capacity of the tricarboxylic acid cycle yields incomplete fat oxidation and mitochondrial distress, obligatory events in the pathogenesis of insulin resistance.Entities:
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Year: 2008 PMID： 18177719 DOI： 10.1016/j.cmet.2007.12.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287