Literature DB >> 18177049

An efficient synthesis and substitution of 3-aroyl-2-bromobenzo[b]furans.

Gurmit S Gill1, Damian W Grobelny, Jason H Chaplin, Bernard L Flynn.   

Abstract

A convenient method for the synthesis of 2-bromo-3-aroyl-benzo[b]furans from readily accessible precursors has been developed. The 2-bromo group has been employed as a versatile synthetic handle in both palladium-mediated couplings and direct nucleophilic substitutions to give access to a wide range of 2-substituted-3-aroyl-benzo[b]furans.

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Year:  2008        PMID： 18177049     DOI： 10.1021/jo701656z

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  A general method for Suzuki-Miyaura coupling reactions using lithium triisopropyl borates.

Authors:  Matthias A Oberli; Stephen L Buchwald
Journal:  Org Lett       Date:  2012-08-15       Impact factor: 6.005

2.  A new palladium precatalyst allows for the fast Suzuki-Miyaura coupling reactions of unstable polyfluorophenyl and 2-heteroaryl boronic acids.

Authors:  Tom Kinzel; Yong Zhang; Stephen L Buchwald
Journal:  J Am Chem Soc       Date:  2010-10-13       Impact factor: 15.419

3.  Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

Authors:  Bernard L Flynn; Gurmit S Gill; Damian W Grobelny; Jason H Chaplin; Dharam Paul; Annabell F Leske; Tina C Lavranos; David K Chalmers; Susan A Charman; Edmund Kostewicz; David M Shackleford; Julia Morizzi; Ernest Hamel; M Katherine Jung; Gabriel Kremmidiotis
Journal:  J Med Chem       Date:  2011-08-05       Impact factor: 7.446

4.  Recyclable Pd/CuFe2O4 nanowires: a highly active catalyst for C-C couplings and synthesis of benzofuran derivatives.

Authors:  Bhairi Lakshminarayana; Jhonti Chakraborty; G Satyanarayana; Ch Subrahmanyam
Journal:  RSC Adv       Date:  2018-06-07       Impact factor: 4.036
  4 in total

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