| Literature DB >> 18176561 |
Anna Helgadottir1, Gudmar Thorleifsson, Kristinn P Magnusson, Solveig Grétarsdottir, Valgerdur Steinthorsdottir, Andrei Manolescu, Gregory T Jones, Gabriel J E Rinkel, Jan D Blankensteijn, Antti Ronkainen, Juha E Jääskeläinen, Yoshiki Kyo, Guy M Lenk, Natzi Sakalihasan, Konstantinos Kostulas, Anders Gottsäter, Andrea Flex, Hreinn Stefansson, Torben Hansen, Gitte Andersen, Shantel Weinsheimer, Knut Borch-Johnsen, Torben Jorgensen, Svati H Shah, Arshed A Quyyumi, Christopher B Granger, Muredach P Reilly, Harland Austin, Allan I Levey, Viola Vaccarino, Ebba Palsdottir, G Bragi Walters, Thorbjorg Jonsdottir, Steinunn Snorradottir, Dana Magnusdottir, Gudmundur Gudmundsson, Robert E Ferrell, Sigurlaug Sveinbjornsdottir, Juha Hernesniemi, Mika Niemelä, Raymond Limet, Karl Andersen, Gunnar Sigurdsson, Rafn Benediktsson, Eric L G Verhoeven, Joep A W Teijink, Diederick E Grobbee, Daniel J Rader, David A Collier, Oluf Pedersen, Roberto Pola, Jan Hillert, Bengt Lindblad, Einar M Valdimarsson, Hulda B Magnadottir, Cisca Wijmenga, Gerard Tromp, Annette F Baas, Ynte M Ruigrok, Andre M van Rij, Helena Kuivaniemi, Janet T Powell, Stefan E Matthiasson, Jeffrey R Gulcher, Gudmundur Thorgeirsson, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson.
Abstract
Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.Entities:
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Year: 2008 PMID： 18176561 DOI： 10.1038/ng.72
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330