OBJECTIVE: To determine risk factors and evaluate the treatment of ethmoid adenocarcinoma. Epidemiologic data were recorded and compared with the literature. MATERIALS AND METHODS: A multicenter and retrospective study. The medical records of 418 patients who had presented with ethmoid adenocarcinoma at 11 French hospitals from 1976 to 2001 were analyzed to determine the clinical characteristics and treatment of the disease. RESULTS: The gender ratio was 2.8 men per 1 woman. Toxic exposure was classic for this lesion, exposure to wood and leather for most cases. The mean age was 63 years (range 31-91). Symptoms were nonspecific and based on clinical rhinologic signs. Nasal endoscopy after mucosal retraction was found useful to evaluate the extension of the lesion and to perform biopsies. Computed tomography scan and magnetic resonance imagery must be carried out prior to treatment to define extra nasal extension. The survival rate was significantly influenced by the size of the lesion (T4, N+) and extension to brain or dura. Surgery with postoperative radiotherapy remains the treatment of choice. Total excision must be a major priority, as confirmed in our series. CONCLUSION: This retrospective study was, to our knowledge, the largest ever reported in the literature. This series confirmed the risk factor of this lesion as well as the lesion's influence on the survival rate. Surgery is the most important part of the treatment. Local recurrences were responsible for the poor prognosis of this lesion.
OBJECTIVE: To determine risk factors and evaluate the treatment of ethmoid adenocarcinoma. Epidemiologic data were recorded and compared with the literature. MATERIALS AND METHODS: A multicenter and retrospective study. The medical records of 418 patients who had presented with ethmoid adenocarcinoma at 11 French hospitals from 1976 to 2001 were analyzed to determine the clinical characteristics and treatment of the disease. RESULTS: The gender ratio was 2.8 men per 1 woman. Toxic exposure was classic for this lesion, exposure to wood and leather for most cases. The mean age was 63 years (range 31-91). Symptoms were nonspecific and based on clinical rhinologic signs. Nasal endoscopy after mucosal retraction was found useful to evaluate the extension of the lesion and to perform biopsies. Computed tomography scan and magnetic resonance imagery must be carried out prior to treatment to define extra nasal extension. The survival rate was significantly influenced by the size of the lesion (T4, N+) and extension to brain or dura. Surgery with postoperative radiotherapy remains the treatment of choice. Total excision must be a major priority, as confirmed in our series. CONCLUSION: This retrospective study was, to our knowledge, the largest ever reported in the literature. This series confirmed the risk factor of this lesion as well as the lesion's influence on the survival rate. Surgery is the most important part of the treatment. Local recurrences were responsible for the poor prognosis of this lesion.
Authors: Shirley Y Su; Michael E Kupferman; Franco DeMonte; Nicholas B Levine; Shaan M Raza; Ehab Y Hanna Journal: Curr Oncol Rep Date: 2014-02 Impact factor: 5.075
Authors: Jhudit Pérez-Escuredo; Jorge García Martínez; Cristina García-Inclán; Blanca Vivanco; María Costales; César Álvarez Marcos; José Luis Llorente; Mario A Hermsen Journal: Cell Oncol (Dordr) Date: 2011-01-18 Impact factor: 6.730
Authors: Santiago Cabezas-Camarero; Virginia de la Orden García; Vanesa García-Barberán; Beatriz Mediero-Valeros; Ahmad Issa Subhi-Issa; Patricia Llovet García; Inmaculada Bando-Polaino; Salomé Merino Menéndez; Pedro Pérez-Segura; Eduardo Díaz-Rubio Journal: Oncologist Date: 2019-01-02
Authors: Antoine Digonnet; Marc Hamoir; Guy Andry; Vincent Vander Poorten; Missak Haigentz; Johannes A Langendijk; Remco de Bree; Michael L Hinni; William M Mendenhall; Vinidh Paleri; Alessandra Rinaldo; Jochen A Werner; Robert P Takes; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2012-10-26 Impact factor: 2.503