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Literature DB >> 18175807

Modulation of apoptosis to reverse chemoresistance.

Gil Mor¹, Michele K Montagna, Ayesha B Alvero.

Abstract

Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the apoptotic cascade has been proposed as a new approach for the treatment of cancer. In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2008 PMID： 18175807 DOI： 10.1007/978-1-59745-339-4_1

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

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Cited

10 in total

1. Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.

Authors: Hsin-Yi Hung; Emika Ohkoshi; Masuo Goto; Kenneth F Bastow; Kyoko Nakagawa-Goto; Kuo-Hsiung Lee
Journal: J Med Chem Date: 2012-05-21 Impact factor: 7.446

2. Targeting the mitochondria activates two independent cell death pathways in ovarian cancer stem cells.

Authors: Ayesha B Alvero; Michele K Montagna; Jennie C Holmberg; Vinicius Craveiro; David Brown; Gil Mor
Journal: Mol Cancer Ther Date: 2011-06-15 Impact factor: 6.261

3. Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation.

Authors: Ying Zou; Ningzhe Zhang; Lisa M Ellerby; Albert R Davalos; Xianmin Zeng; Judith Campisi; Pierre-Yves Desprez
Journal: Biochem Biophys Res Commun Date: 2012-08-14 Impact factor: 3.575

4. Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer.

Authors: Jan B Howes; Paul L de Souza; Leanne West; Li Jiu Huang; Laurence G Howes
Journal: BMC Clin Pharmacol Date: 2011-02-03

5. A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy.

Authors: W He; Q Wang; B Srinivasan; J Xu; M T Padilla; Z Li; X Wang; Y Liu; X Gou; H-M Shen; C Xing; Y Lin
Journal: Oncogene Date: 2013-07-08 Impact factor: 9.867

6. An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation.

Authors: Han-Lin Chou; Yao Fong; Hsin-Hsien Lin; Eing Mei Tsai; Jeff Yi-Fu Chen; Wen-Tsan Chang; Chang-Yi Wu; Hui-Min David Wang; Hurng-Wern Huang; Chien-Chih Chiu
Journal: Oxid Med Cell Longev Date: 2016-10-24 Impact factor: 6.543

Modulation of apoptosis to reverse chemoresistance.

1. Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.

2. Targeting the mitochondria activates two independent cell death pathways in ovarian cancer stem cells.

3. Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation.

4. Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer.

5. A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy.

6. An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation.

7. Chalcone-Induced Apoptosis through Caspase-Dependent Intrinsic Pathways in Human Hepatocellular Carcinoma Cells.

8. Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells.

Review 9. The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy.

10. PROM2 promotes gemcitabine chemoresistance via activating the Akt signaling pathway in pancreatic cancer.