BACKGROUND: It is hypothesized that low dietary fat oxidation makes subjects prone to weight gain. OBJECTIVE: The aim of the study was to determine dietary fat oxidation in normal, overweight, and obese subjects. DESIGN: The subjects were 38 women and 18 men with a mean (+/-SD) age of 30+/-12 y and a body mass index (in kg/m2) of 25+/-4 (range: 18-39). Dietary fat oxidation was measured with deuterated palmitic acid, given simultaneously with breakfast, while the subjects were fed under controlled conditions in a respiration chamber. Body composition was measured by hydrodensitometry and deuterium dilution. RESULTS: Dietary fat oxidation, measured over 12 h after breakfast, ranged from 4% to 28% with a mean (+/-SD) of 16+/-6%. Dietary fat oxidation was negatively related to percentage body fat, and lean subjects had the highest and obese subjects the lowest values (r=-0.65, P<0.001). CONCLUSION: The observed reduction in dietary fat oxidation in subjects with a higher percentage body fat may play a role in human obesity.
BACKGROUND: It is hypothesized that low dietary fat oxidation makes subjects prone to weight gain. OBJECTIVE: The aim of the study was to determine dietary fat oxidation in normal, overweight, and obese subjects. DESIGN: The subjects were 38 women and 18 men with a mean (+/-SD) age of 30+/-12 y and a body mass index (in kg/m2) of 25+/-4 (range: 18-39). Dietary fat oxidation was measured with deuterated palmitic acid, given simultaneously with breakfast, while the subjects were fed under controlled conditions in a respiration chamber. Body composition was measured by hydrodensitometry and deuterium dilution. RESULTS: Dietary fat oxidation, measured over 12 h after breakfast, ranged from 4% to 28% with a mean (+/-SD) of 16+/-6%. Dietary fat oxidation was negatively related to percentage body fat, and lean subjects had the highest and obese subjects the lowest values (r=-0.65, P<0.001). CONCLUSION: The observed reduction in dietary fat oxidation in subjects with a higher percentage body fat may play a role in humanobesity.
Authors: E Lefai; S Blanc; I Momken; E Antoun; I Chery; A Zahariev; L Gabert; A Bergouignan; C Simon Journal: Int J Obes (Lond) Date: 2017-07-03 Impact factor: 5.095
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