Jeong-Min Hwang1, Jung-Eun Cheon, Kyu-Chang Wang. 1. Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Sungnam, Korea.
Abstract
BACKGROUND: Optic gliomas may unpredictably stabilize or progress. Prognosis was known to be better in patients with neurofibromatosis 1 (NF1) than those with non-NF1. The confusion over management is caused, at least in part, by the uncertain disease course of the tumor. CASE HISTORY: We report here a 13-year-old girl presented with a 1-month history of a gradual decline of vision in her left eye. She was diagnosed by clinical examination and magnetic resonance imaging as having a left optic-nerve glioma and was followed by serial magnetic resonance imaging over 3 years. She and her family did not show any stigmata of NF1. Approximately 3 years after the onset of her symptoms, visual acuity, color testing, and visual fields have markedly improved with tumor regression by magnetic resonance imaging. CONCLUSIONS: The possibility of spontaneous regression of an optic-nerve glioma should be considered even in the planning of treatment for a non-NF1 patient with this tumor.
BACKGROUND: Optic gliomas may unpredictably stabilize or progress. Prognosis was known to be better in patients with neurofibromatosis 1 (NF1) than those with non-NF1. The confusion over management is caused, at least in part, by the uncertain disease course of the tumor. CASE HISTORY: We report here a 13-year-old girl presented with a 1-month history of a gradual decline of vision in her left eye. She was diagnosed by clinical examination and magnetic resonance imaging as having a left optic-nerve glioma and was followed by serial magnetic resonance imaging over 3 years. She and her family did not show any stigmata of NF1. Approximately 3 years after the onset of her symptoms, visual acuity, color testing, and visual fields have markedly improved with tumor regression by magnetic resonance imaging. CONCLUSIONS: The possibility of spontaneous regression of an optic-nerve glioma should be considered even in the planning of treatment for a non-NF1patient with this tumor.
Authors: C F Parsa; C S Hoyt; R L Lesser; J M Weinstein; C M Strother; R Muci-Mendoza; M Ramella; R S Manor; W A Fletcher; M X Repka; J A Garrity; R N Ebner; M L Monteiro; R M McFadzean; I V Rubtsova; W F Hoyt Journal: Arch Ophthalmol Date: 2001-04