Literature DB >> 18175085

Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.

A Zeller1, R Jurd, S Lambert, M Arras, B Drexler, C Grashoff, B Antkowiak, U Rudolph.   

Abstract

General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)(A) receptor subtypes in anesthetic actions could be demonstrated by genetic studies in vivo.

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Year:  2008        PMID： 18175085     DOI： 10.1007/978-3-540-74806-9_2

Source DB:  PubMed          Journal:  Handb Exp Pharmacol        ISSN： 0171-2004


  15 in total

1.  Dihydropyrimidinone positive modulation of delta-subunit-containing gamma-aminobutyric acid type A receptors, including an epilepsy-linked mutant variant.

Authors:  Ryan W Lewis; John Mabry; Jason G Polisar; Kyle P Eagen; Bruce Ganem; George P Hess
Journal:  Biochemistry       Date:  2010-06-15       Impact factor: 3.162

2.  EEG artifacts reduction by multivariate empirical mode decomposition and multiscale entropy for monitoring depth of anaesthesia during surgery.

Authors:  Quan Liu; Yi-Feng Chen; Shou-Zen Fan; Maysam F Abbod; Jiann-Shing Shieh
Journal:  Med Biol Eng Comput       Date:  2016-12-19       Impact factor: 2.602

3.  Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.

Authors:  Zaineb Fourati; Reinis Reinholds Ruza; Duncan Laverty; Emmanuelle Drège; Sandrine Delarue-Cochin; Delphine Joseph; Patrice Koehl; Trevor Smart; Marc Delarue
Journal:  J Biol Chem       Date:  2016-12-16       Impact factor: 5.157

4.  Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.

Authors:  Rooma Desai; Pavel Y Savechenkov; Dorota Zolkowska; Ri Le Ge; Michael A Rogawski; Karol S Bruzik; Stuart A Forman; Douglas E Raines; Keith W Miller
Journal:  J Physiol       Date:  2015-11-15       Impact factor: 5.182

Review 5.  Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.

Authors:  Stuart A Forman; Keith W Miller
Journal:  Can J Anaesth       Date:  2011-01-07       Impact factor: 5.063

6.  General anesthetic actions on GABAA receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice.

Authors:  Masaki Hayashiuchi; Tomoya Kitayama; Katsuya Morita; Yosuke Yamawaki; Kana Oue; Taiga Yoshinaka; Satoshi Asano; Kae Harada; Youngnam Kang; Masato Hirata; Masahiro Irifune; Mitsugi Okada; Takashi Kanematsu
Journal:  J Anesth       Date:  2017-04-07       Impact factor: 2.078

7.  Propofol facilitates glutamatergic transmission to neurons of the ventrolateral preoptic nucleus.

Authors:  Ke Y Li; Yan-zhong Guan; Kresimir Krnjević; Jiang H Ye
Journal:  Anesthesiology       Date:  2009-12       Impact factor: 7.892

8.  Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.

Authors:  Ludovic Sauguet; Rebecca J Howard; Laurie Malherbe; Ui S Lee; Pierre-Jean Corringer; R Adron Harris; Marc Delarue
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

Review 9.  Glycine as a neurotransmitter in the forebrain: a short review.

Authors:  Marina Sorrentino Hernandes; Lanfranco R P Troncone
Journal:  J Neural Transm (Vienna)       Date:  2009-10-14       Impact factor: 3.575

10.  Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavities.

Authors:  Borna Ghosh; Kenneth A Satyshur; Cynthia Czajkowski
Journal:  J Biol Chem       Date:  2013-05-02       Impact factor: 5.157
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