BACKGROUND: Cigarette smoking is a known risk factor for cardiovascular disease (CVD), but its relationship to the development of hypertension is unclear. Previous epidemiological studies have shown inconsistent results, having demonstrated inverse and positive associations between cigarette smoking and the development of hypertension. METHODS: We analyzed 13,529 male participants from the Physicians' Health Study free of baseline hypertension and CVD who provided information about smoking status. Smoking status was categorized as never, past, or current <20 cigarettes/day, or current > or =20 cigarettes/day. Incident hypertension was defined as either the initiation of antihypertensive treatment, self-reported systolic blood pressure (BP) > or =140 mm Hg, or diastolic BP > or =90 mm Hg. RESULTS: Over a median follow-up of 14.5 years, 4,904 men developed hypertension. We modeled the risk of developing hypertension by baseline smoking status adjusting for known risk factors for hypertension or CVD. In a fully adjusted Cox proportional hazards model, we found that compared with never smokers, past smokers and current smokers had corresponding relative risks (RRs) of 1.08 and 1.15 of developing hypertension. The risk for smokers did not appear to differ based on number of cigarettes smoked daily. Further, the RR of hypertension was higher for men with normal vs. prehypertensive levels of systolic (SBP) or diastolic BP (DBP). CONCLUSIONS: This prospective cohort data suggests that cigarette smoking may be a modest but important risk factor for the development of hypertension.
BACKGROUND: Cigarette smoking is a known risk factor for cardiovascular disease (CVD), but its relationship to the development of hypertension is unclear. Previous epidemiological studies have shown inconsistent results, having demonstrated inverse and positive associations between cigarette smoking and the development of hypertension. METHODS: We analyzed 13,529 male participants from the Physicians' Health Study free of baseline hypertension and CVD who provided information about smoking status. Smoking status was categorized as never, past, or current <20 cigarettes/day, or current > or =20 cigarettes/day. Incident hypertension was defined as either the initiation of antihypertensive treatment, self-reported systolic blood pressure (BP) > or =140 mm Hg, or diastolic BP > or =90 mm Hg. RESULTS: Over a median follow-up of 14.5 years, 4,904 men developed hypertension. We modeled the risk of developing hypertension by baseline smoking status adjusting for known risk factors for hypertension or CVD. In a fully adjusted Cox proportional hazards model, we found that compared with never smokers, past smokers and current smokers had corresponding relative risks (RRs) of 1.08 and 1.15 of developing hypertension. The risk for smokers did not appear to differ based on number of cigarettes smoked daily. Further, the RR of hypertension was higher for men with normal vs. prehypertensive levels of systolic (SBP) or diastolic BP (DBP). CONCLUSIONS: This prospective cohort data suggests that cigarette smoking may be a modest but important risk factor for the development of hypertension.
Authors: Deepa M Gopal; Andreas P Kalogeropoulos; Vasiliki V Georgiopoulou; Andrew L Smith; Douglas C Bauer; Anne B Newman; Lauren Kim; Kirsten Bibbins-Domingo; Hillary Tindle; Tamara B Harris; Wilson W H Tang; Stephen B Kritchevsky; Javed Butler Journal: Am Heart J Date: 2012-08 Impact factor: 4.749
Authors: Daniel J Conklin; Suzaynn Schick; Michael J Blaha; Alex Carll; Andrew DeFilippis; Peter Ganz; Michael E Hall; Naomi Hamburg; Tim O'Toole; Lindsay Reynolds; Sanjay Srivastava; Aruni Bhatnagar Journal: Am J Physiol Heart Circ Physiol Date: 2019-02-01 Impact factor: 4.733
Authors: Nadia A Khan; Brenda Hemmelgarn; Robert J Herman; Chaim M Bell; Jeff L Mahon; Lawrence A Leiter; Simon W Rabkin; Michael D Hill; Raj Padwal; Rhian M Touyz; Pierre Larochelle; Ross D Feldman; Ernesto L Schiffrin; Norman R C Campbell; Gordon Moe; Ramesh Prasad; Malcolm O Arnold; Tavis S Campbell; Alain Milot; James A Stone; Charlotte Jones; Richard I Ogilvie; Pavel Hamet; George Fodor; George Carruthers; Kevin D Burns; Marcel Ruzicka; Jacques DeChamplain; George Pylypchuk; Robert Petrella; Jean-Martin Boulanger; Luc Trudeau; Robert A Hegele; Vincent Woo; Phil McFarlane; Michel Vallée; Jonathan Howlett; Simon L Bacon; Patrice Lindsay; Richard E Gilbert; Richard Z Lewanczuk; Sheldon Tobe Journal: Can J Cardiol Date: 2009-05 Impact factor: 5.223