Literature DB >> 18172635

Imaging findings of upper abdominal involvement by acute megakaryoblastic leukaemia.

Shiori Amemiya1, Masaaki Akahane, Junko Takita, Takashi Igarashi, Kuni Ohtomo.   

Abstract

Acute megakaryoblastic leukaemia (AMKL), a relatively rare type of acute myeloid leukaemia, is characterized by frequent involvement of the liver, spleen and lymph nodes in addition to myelofibrosis in children. Diagnosis is difficult both clinically and pathologically, and the hepatic or lymph node involvement is not uncommonly misinterpreted as solid tumour. We report the imaging findings of upper abdominal involvement by AMKL in an infant. The hepatic lesion, initially suspected to be hepatoblastoma, showed a distinctive appearance on MRI suggesting its infiltrative nature. With the association of splenic lesion and lymphadenopathy, the imaging findings were considered indicative of a haematological disorder.

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Year:  2008        PMID: 18172635     DOI: 10.1007/s00247-007-0719-3

Source DB:  PubMed          Journal:  Pediatr Radiol        ISSN: 0301-0449


  6 in total

1.  Hepatic involvement by congenital megakaryocytic leukemia in a neonate: sonographic features.

Authors:  J Gong; S Jéquier; M A Brundler; F Gumy-Pausc; P Wacker
Journal:  AJR Am J Roentgenol       Date:  1999-10       Impact factor: 3.959

Review 2.  Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group.

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Journal:  Leukemia       Date:  2000-01       Impact factor: 11.528

3.  Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment.

Authors:  D Reinhardt; S Diekamp; C Langebrake; J Ritter; J Stary; M Dworzak; A Schrauder; M Zimmermann; G Fleischhack; W-D Ludwig; J Harbott; U Creutzig
Journal:  Leukemia       Date:  2005-08       Impact factor: 11.528

4.  Diffuse disease of the liver: radiologic-pathologic correlation.

Authors:  P J Mergo; P R Ros; P C Buetow; J L Buck
Journal:  Radiographics       Date:  1994-11       Impact factor: 5.333

5.  Acute megakaryoblastic leukemia in infants with t(1;22)(p13;q13) abnormality.

Authors:  W C Chan; A Carroll; C S Alvarado; S Phillips; F Gonzalez-Crussi; E Kurczynski; A Pappo; A Emami; P Bowman; D R Head
Journal:  Am J Clin Pathol       Date:  1992-08       Impact factor: 2.493

6.  Pathology of the liver in leukaemia and lymphoma. A study of 110 autopsies.

Authors:  I B Scheimberg; D J Pollock; P W Collins; H M Doran; A C Newland; J D van der Walt
Journal:  Histopathology       Date:  1995-04       Impact factor: 5.087

  6 in total

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