Literature DB >> 18172517

Antipsychotics in the treatment of autism.

David J Posey1, Kimberly A Stigler, Craig A Erickson, Christopher J McDougle.   

Abstract

Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed.

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Year:  2008        PMID： 18172517      PMCID： PMC2171144          DOI： 10.1172/JCI32483

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  87 in total

1.  Long-term efficacy of haloperidol in autistic children: continuous versus discontinuous drug administration.

Authors:  R Perry; M Campbell; P Adams; N Lynch; E K Spencer; E L Curren; J E Overall
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  1989-01       Impact factor: 8.829

2.  Serotonergic responsivity in male young adults with autistic disorder. Results of a pilot study.

Authors:  P A McBride; G M Anderson; M E Hertzig; J A Sweeney; J Kream; D J Cohen; J J Mann
Journal:  Arch Gen Psychiatry       Date:  1989-03

3.  CSF monoamines in autistic syndromes and other pervasive developmental disorders of early childhood.

Authors:  C Gillberg; L Svennerholm
Journal:  Br J Psychiatry       Date:  1987-07       Impact factor: 9.319

4.  The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children.

Authors:  L T Anderson; M Campbell; P Adams; A M Small; R Perry; J Shell
Journal:  J Autism Dev Disord       Date:  1989-06

5.  A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients.

Authors:  G Chouinard; B Jones; G Remington; D Bloom; D Addington; G W MacEwan; A Labelle; L Beauclair; W Arnott
Journal:  J Clin Psychopharmacol       Date:  1993-02       Impact factor: 3.153

6.  Catecholamines metabolism in infantile autism: a controlled study of 22 autistic children.

Authors:  J M Launay; C Bursztejn; P Ferrari; C Dreux; A Braconnier; E Zarifian; S Lancrenon; J Fermanian
Journal:  J Autism Dev Disord       Date:  1987-09

7.  Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS).

Authors:  E Schopler; R J Reichler; R F DeVellis; K Daly
Journal:  J Autism Dev Disord       Date:  1980-03

8.  Neurochemical study of dopamine functioning in autistic and normal subjects.

Authors:  R B Minderaa; G M Anderson; F R Volkmar; G W Akkerhuis; D J Cohen
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  1989-03       Impact factor: 8.829

9.  Whole blood serotonin in autistic and normal subjects.

Authors:  G M Anderson; D X Freedman; D J Cohen; F R Volkmar; E L Hoder; P McPhedran; R B Minderaa; C R Hansen; J G Young
Journal:  J Child Psychol Psychiatry       Date:  1987-11       Impact factor: 8.982

10.  The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders.

Authors:  D E Comings; B G Comings; D Muhleman; G Dietz; B Shahbahrami; D Tast; E Knell; P Kocsis; R Baumgarten; B W Kovacs
Journal:  JAMA       Date:  1991-10-02       Impact factor: 56.272
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  37 in total

Review 1.  Emerging drugs for the treatment of symptoms associated with autism spectrum disorders.

Authors:  Logan K Wink; Martin H Plawecki; Craig A Erickson; Kimberly A Stigler; Christopher J McDougle
Journal:  Expert Opin Emerg Drugs       Date:  2010-09       Impact factor: 4.191

2.  Psychotropic medication use among children with autism spectrum disorders enrolled in a national registry, 2007-2008.

Authors:  Rebecca E Rosenberg; David S Mandell; Janet E Farmer; J Kiely Law; Alison R Marvin; Paul A Law
Journal:  J Autism Dev Disord       Date:  2010-03

3.  Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6-17 years.

Authors:  Kelly Blankenship; Craig A Erickson; Kimberly A Stigler; David J Posey; Christopher J McDougle
Journal:  Ped Health       Date:  2010-09-29

Review 4.  Multidisciplinary assessment and treatment of self-injurious behavior in autism spectrum disorder and intellectual disability: integration of psychological and biological theory and approach.

Authors:  Noha F Minshawi; Sarah Hurwitz; Danielle Morriss; Christopher J McDougle
Journal:  J Autism Dev Disord       Date:  2015-06

5.  Brief Report: Metformin for Antipsychotic-Induced Weight Gain in Youth with Autism Spectrum Disorder.

Authors:  Logan K Wink; Ryan Adams; Ernest V Pedapati; Kelli C Dominick; Emma Fox; Catherine Buck; Craig A Erickson
Journal:  J Autism Dev Disord       Date:  2017-07

Review 6.  Adenosine and autism: a spectrum of opportunities.

Authors:  Susan A Masino; Masahito Kawamura; Jessica L Cote; Rebecca B Williams; David N Ruskin
Journal:  Neuropharmacology       Date:  2012-08-24       Impact factor: 5.250

7.  Risperidone administered during asymptomatic period of adolescence prevents the emergence of brain structural pathology and behavioral abnormalities in an animal model of schizophrenia.

Authors:  Yael Piontkewitz; Michal Arad; Ina Weiner
Journal:  Schizophr Bull       Date:  2010-05-03       Impact factor: 9.306

8.  An open-label extension study of the safety and efficacy of risperidone in children and adolescents with autistic disorder.

Authors:  Justine M Kent; David Hough; Jaskaran Singh; Keith Karcher; Gahan Pandina
Journal:  J Child Adolesc Psychopharmacol       Date:  2013-12       Impact factor: 2.576

9.  Is Medication Information for Children with Autism Spectrum Disorder Monitored and Coordinated Across Professionals? Findings from a Teacher Survey.

Authors:  Lynn K Koegel; Anna M Krasno; Howard Taras; Robert L Koegel; William Frea
Journal:  School Ment Health       Date:  2013-02-06

Review 10.  Aripiprazole for autism spectrum disorders (ASD).

Authors:  Lauren E Hirsch; Tamara Pringsheim
Journal:  Cochrane Database Syst Rev       Date:  2016-06-26
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