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Literature DB >> 181688

Interaction of digitoxigenin with lecithin membranes.

Abstract

The binding of digitoxigenin to lecithin model membranes was investigated by application of electron spin- and nuclear magnetic resonance methods. A digitoxigenin spin-label derivative was found to bind specifically to the pseudohexagonal rigid lattice of lecithin membranes. The binding is accomplished by some of the structural features which are required for the biological activity of cardiac glycosides. Digitoxigenin has a procooperative effect on dipalmitoyl-lecithin membranes. The induction of lipid phase separation is discussed as a hypothetic molecular mechanism of action of cardiac glycosides on biological membranes.

Entities: Chemical

Mesh：

Substances：

Year: 1976 PMID： 181688 DOI： 10.1007/bf00498869

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

28 in total

1. The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers.

Authors: J R Trudell; D G Payan; J H Chin; E N Cohen
Journal: Proc Natl Acad Sci U S A Date: 1975-01 Impact factor: 11.205

2. Lateral phase separation in phospholipid membranes.

Authors: E J Shimshick; H M McConnell
Journal: Biochemistry Date: 1973-06-05 Impact factor: 3.162

3. Clustering of lecithin molecules in phosphatidylserine membranes induced by calcium ion binding to phosphatidylserine.

Authors: S Ohnishi; T Ito
Journal: Biochem Biophys Res Commun Date: 1973-03-05 Impact factor: 3.575

Interaction of digitoxigenin with lecithin membranes.

1. The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers.

2. Lateral phase separation in phospholipid membranes.

3. Clustering of lecithin molecules in phosphatidylserine membranes induced by calcium ion binding to phosphatidylserine.

4. Reconstitution of a calcium pump using defined membrane components.

Review 5. The subcellular basis for the mechanism of inotropic action of cardiac glycosides.

Review 6. Physics and chemistry of spin labels.

7. An effect of ouabain on the superficially-located stores of calcium in cardiac muscle cells.

8. Influence of cardiac glycosides on calcium binding in muscle subcellular components.

9. Evidence for boundary lipid in membranes.

10. Influence of ouabain and dihydroouabain on the circular dichroism of cardiac plasmalemmal microsomes.

1. Effects of cardiac aglycones on the sodium efflux in barnacle muscle fibres.