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Literature DB >> 181684

Adrenal cortex adenylate cyclase. Is Ca2+ involved in ACTH stimulation?

Abstract

The chelator EGTA inhibits the activation of bovine adrenal cortex adenylate cyclase by ACTH. Hormonal response is restored by addition of Ca2+, Mn2+ and other cations which are able to significantly reduce the concentration of uncomplexed EGTA in the adenylate cyclase assy medium. Time course studies reveal that the enzyme in the activated state (induced by adenylate cyclase reagents and hormone or by pretreatment with hormone) is resistant to EGTA inhibition.

Entities: Chemical Species

Mesh：

Substances：

Year: 1976 PMID： 181684 DOI： 10.1007/bf00498593

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

15 in total

1. Bovine adrenal cortex adenylate cyclase: properties of the particulate enzyme and effects of guanyl nucleotides.

Authors: H Glossmann; H Gips
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

2. Multiple inhibitory and activating effects of nucleotides and magnesium on adrenal adenylate cyclase.

Authors: C Londos; M Rodbell
Journal: J Biol Chem Date: 1975-05-10 Impact factor: 5.157

3. Role of Ca2+ in adrenocorticotropic hormone-stimulated lipolysis in the perfused fat cell system.

Authors: A S Katocs; E E Largis; D O Allen
Journal: J Biol Chem Date: 1974-04-10 Impact factor: 5.157

4. Effects of calcium and theophylline on ACTH- and dibutyryl cyclic AMP-stimulated steroidogenesis and glycolysis by intact mouse adrenal glands in vitro.

Authors: M K Birmingham; A Bartová
Journal: Endocrinology Date: 1973-03 Impact factor: 4.736

Review 5. The role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multi-site transition states.

Authors: M Rodbell; M C Lin; Y Salomon; C Londos; J P Harwood; B R Martin; M Rendell; M Berman
Journal: Acta Endocrinol Suppl (Copenh) Date: 1974

6. Adrenal cortex adenylate cyclase. Comparison between the action of GTP and 5'-guanylyl-imidodiphosphate on the particulate enzyme from bovine adrenal cortex and rat adrenals.

Authors: H Glossmann; H Gips
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1974 Impact factor: 3.000

Adrenal cortex adenylate cyclase. Is Ca2+ involved in ACTH stimulation?

1. Bovine adrenal cortex adenylate cyclase: properties of the particulate enzyme and effects of guanyl nucleotides.

2. Multiple inhibitory and activating effects of nucleotides and magnesium on adrenal adenylate cyclase.

3. Role of Ca2+ in adrenocorticotropic hormone-stimulated lipolysis in the perfused fat cell system.

4. Effects of calcium and theophylline on ACTH- and dibutyryl cyclic AMP-stimulated steroidogenesis and glycolysis by intact mouse adrenal glands in vitro.

Review 5. The role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multi-site transition states.

6. Adrenal cortex adenylate cyclase. Comparison between the action of GTP and 5'-guanylyl-imidodiphosphate on the particulate enzyme from bovine adrenal cortex and rat adrenals.

7. Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation.

8. Adenyl cyclase in fat cells. II. Hormone receptors.

9. A highly sensitive adenylate cyclase assay.

10. Adenyl cyclase and hormone action. 3. Calcium requirement for ACTH stimulation of adenyl cyclase.

1. Adrenal cortex adenylate cyclase. In vitro modification of the enzyme by cholera toxin.