BACKGROUND: For patients suffering from complex coronary artery disease (CAD) with or without concomitant valve disease, no evidence is available in the current guidelines to propose a predefined treatment regimen. We sought to assess the clinical impact of an unconventional or extended definition of the hybrid approach that combines percutaneous coronary intervention (PCI) and cardiac surgery in subjects suffering from severe solitary CAD or combined with valve disease. METHODS AND RESULTS: Between July 2002 and August 2004, 18 consecutive patients with complex CAD with or without significant valve disease who qualified for a hybrid approach were enrolled in a clinical follow-up study. Four patients eventually did not complete the proposed interventions. One patient refused treatment after inclusion, one patient died before treatment could be undertaken and two patients died after surgery but before PCI. In the other 14 cases combined treatment was technically successful. After a mean follow-up period of 15alpha5 months two patients had died, one due to sudden cardiac death and one of a noncardiac cause. No other major adverse clinical events were reported. A marked increase in quality of life was reported in those alive. CONCLUSION: Hybrid approach had a favourable long-term outcome in patients with complex cardiovascular disease undergoing successful treatment; however, this was observed at the expense of significant periprocedural mortality in these high-risk subjects. Therefore we believe that hybrid approaches may provide an alternative for selected cases. (Neth Heart J 2007;15:329-4.).
BACKGROUND: For patients suffering from complex coronary artery disease (CAD) with or without concomitant valve disease, no evidence is available in the current guidelines to propose a predefined treatment regimen. We sought to assess the clinical impact of an unconventional or extended definition of the hybrid approach that combines percutaneous coronary intervention (PCI) and cardiac surgery in subjects suffering from severe solitary CAD or combined with valve disease. METHODS AND RESULTS: Between July 2002 and August 2004, 18 consecutive patients with complex CAD with or without significant valve disease who qualified for a hybrid approach were enrolled in a clinical follow-up study. Four patients eventually did not complete the proposed interventions. One patient refused treatment after inclusion, one patient died before treatment could be undertaken and two patients died after surgery but before PCI. In the other 14 cases combined treatment was technically successful. After a mean follow-up period of 15alpha5 months two patients had died, one due to sudden cardiac death and one of a noncardiac cause. No other major adverse clinical events were reported. A marked increase in quality of life was reported in those alive. CONCLUSION: Hybrid approach had a favourable long-term outcome in patients with complex cardiovascular disease undergoing successful treatment; however, this was observed at the expense of significant periprocedural mortality in these high-risk subjects. Therefore we believe that hybrid approaches may provide an alternative for selected cases. (Neth Heart J 2007;15:329-4.).
Authors: John G Byrne; Marzia Leacche; Daniel Unic; James D Rawn; Daniel I Simon; Campbell D Rogers; Lawrence H Cohn Journal: J Am Coll Cardiol Date: 2005-01-04 Impact factor: 24.094
Authors: H A Cohen; M Zenati; A J Smith; J S Lee; S Chough; Z Jafar; P Counihan; M Izzo; J E Burchenal; A M Feldman; B Griffith Journal: Circulation Date: 1998-09-15 Impact factor: 29.690
Authors: T Wittwer; J Cremer; P Boonstra; J Grandjean; M Mariani; A Mügge; H Drexler; P den Heijer; E R Leitner; A Hepp; M Wehr; A Haverich Journal: Heart Date: 2000-01 Impact factor: 5.994
Authors: Thomas A Vassiliades; John S Douglas; Douglas C Morris; Peter C Block; Ziyad Ghazzal; S Tanveer Rab; Christopher U Cates Journal: J Thorac Cardiovasc Surg Date: 2006-04-27 Impact factor: 5.209
Authors: P Presbitero; R Gallotti; G Belli; G Franciosi; L Maiello; F Nicolini; E Manasse; E Citterio; A Carcagnì; A Foresti Journal: G Ital Cardiol Date: 1999-01