Literature DB >> 18167335

Autocrine IL-6 signaling: a key event in tumorigenesis?

Sergei Grivennikov1, Michael Karin.   

Abstract

Tumorigenesis is a multistep process that requires constitutive cell division, growth, and survival. One strategy used by cancer cells to upregulate growth and survival pathways is through autocrine production of growth and survival factors. Two recent papers by Gao et al. and Sansone et al. published in The Journal of Clinical Investigation outline the importance of autocrine interleukin 6 (IL-6) in lung and breast cancers and implicate IL-6 as an important activator of oncogenic STAT3 in lung adenocarcinomas and of Jagged-1/Notch signaling in breast tumor mammospheres.

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Year:  2008        PMID： 18167335     DOI： 10.1016/j.ccr.2007.12.020

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  158 in total

Review 1.  Role of TLR2-dependent inflammation in metastatic progression.

Authors:  Sunhwa Kim; Michael Karin
Journal:  Ann N Y Acad Sci       Date:  2011-01       Impact factor: 5.691

2.  HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis.

Authors:  Zachary C Hartman; Xiao-Yi Yang; Oliver Glass; Gangjun Lei; Takuya Osada; Sandeep S Dave; Michael A Morse; Timothy M Clay; Herbert K Lyerly
Journal:  Cancer Res       Date:  2011-04-25       Impact factor: 12.701

3.  Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia.

Authors:  Michael Quante; Govind Bhagat; Julian A Abrams; Frederic Marache; Pamela Good; Michele D Lee; Yoomi Lee; Richard Friedman; Samuel Asfaha; Zinaida Dubeykovskaya; Umar Mahmood; Jose-Luiz Figueiredo; Jan Kitajewski; Carrie Shawber; Charles J Lightdale; Anil K Rustgi; Timothy C Wang
Journal:  Cancer Cell       Date:  2012-01-17       Impact factor: 31.743

4.  Peering into the aftermath: JAKi rips STAT3 in cancer.

Authors:  Florian R Greten; Michael Karin
Journal:  Nat Med       Date:  2010-10       Impact factor: 53.440

5.  Magnetic assembly of 3D cell clusters: visualizing the formation of an engineered tissue.

Authors:  S Ghosh; S R P Kumar; I K Puri; S Elankumaran
Journal:  Cell Prolif       Date:  2016-02-02       Impact factor: 6.831

6.  A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer.

Authors:  Joong-Jae Lee; Hyun Jung Kim; Chul-Su Yang; Hyun-Ho Kyeong; Jung-Min Choi; Da-Eun Hwang; Jae-Min Yuk; Keunwan Park; Yu Jung Kim; Seung-Goo Lee; Dongsup Kim; Eun-Kyeong Jo; Hae-Kap Cheong; Hak-Sung Kim
Journal:  Mol Ther       Date:  2014-03-31       Impact factor: 11.454

7.  Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.

Authors:  Sabina Pucci; Paola Mazzarelli; Mazzarelli Paola; Fabiola Sesti; Sesti Fabiola; David A Boothman; Boothman A David; Luigi G Spagnoli; Spagnoli G Luigi
Journal:  Cell Cycle       Date:  2009-02-18       Impact factor: 4.534

Review 8.  Barrett esophagus: what a mouse model can teach us about human disease.

Authors:  Michael Quante; Julian A Abrams; Yoomi Lee; Timothy C Wang
Journal:  Cell Cycle       Date:  2012-10-24       Impact factor: 4.534

9.  Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.

Authors:  Anita S Galvez; Angeles Duran; Juan F Linares; Peterson Pathrose; Elias A Castilla; Shadi Abu-Baker; Michael Leitges; Maria T Diaz-Meco; Jorge Moscat
Journal:  Mol Cell Biol       Date:  2008-10-27       Impact factor: 4.272

Review 10.  Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer.

Authors:  Sergei I Grivennikov; Michael Karin
Journal:  Cytokine Growth Factor Rev       Date:  2009-12-16       Impact factor: 7.638
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