Literature DB >> 1816724

Effect of sho-saiko-to(xiao-chai-hu-tang) on HBeAg clearance in children with chronic hepatitis B virus infection and with sustained liver disease.

H Tajiri1, K Kozaiwa, Y Ozaki, K Miki, K Shimuzu, S Okada.   

Abstract

We studied the effect of Sho-saiko-to (Xiao-Chai-Hu-Tang) on HBeAg clearance rate (SN rate) in fourteen children with chronic hepatitis B virus (HBV) infection and with sustained liver disease. Seven of fourteen patients (50.0%) became HBeAg negative in the average observation period of 0.47 years(0.2-0.9 years). Four of those seven patients developed anti-HBe. The annual SN rate in the She-saiko-to treated group was apparently higher than the natural annual SN rate (22.7%) of 22 untreated patients retrospectively reviewed from the onset of hepatitis. Sho-saiko-to seemed to promote clearance of HBeAg in children with chronic HBV infection and with sustained liver disease. Sho-saiko-to may be a useful drug for such patients.

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Year:  1991        PMID： 1816724     DOI： 10.1142/S0192415X91000193

Source DB:  PubMed          Journal:  Am J Chin Med        ISSN： 0192-415X            Impact factor:   4.667


  16 in total

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