OBJECTIVE: Fruit and vegetable intake may protect against gastric cancer incidence. Results from case-control studies have indicated an inverse association, but results from cohort studies are inconsistent. METHODS: We prospectively investigated the association in 490,802 participants of the NIH-AARP Diet and Health Study using Cox proportional hazards models adjusted for gastric cancer risk factors. We present hazard ratios (HR) and 95% confidence intervals (CI) per increase of one daily serving per 1,000 calories. RESULTS: During 2,193,751 person years, 394 participants were diagnosed with incident gastric cancer. We observed no significant associations between total fruit and vegetable intake (1.01, 0.95-1.08), fruit intake (1.04, 0.95-1.14), or vegetable intake (0.98, 0.88-1.08) and gastric cancer risk. Results did not vary by sex or anatomic subsite (cardia versus non-cardia). All 13 botanical subgroups examined had no significant associations with either anatomic sub-site. CONCLUSION: We did not observe significant associations between overall fruit and vegetable intake and gastric cancer risk in this large prospective cohort study.
OBJECTIVE: Fruit and vegetable intake may protect against gastric cancer incidence. Results from case-control studies have indicated an inverse association, but results from cohort studies are inconsistent. METHODS: We prospectively investigated the association in 490,802 participants of the NIH-AARP Diet and Health Study using Cox proportional hazards models adjusted for gastric cancer risk factors. We present hazard ratios (HR) and 95% confidence intervals (CI) per increase of one daily serving per 1,000 calories. RESULTS: During 2,193,751 person years, 394 participants were diagnosed with incident gastric cancer. We observed no significant associations between total fruit and vegetable intake (1.01, 0.95-1.08), fruit intake (1.04, 0.95-1.14), or vegetable intake (0.98, 0.88-1.08) and gastric cancer risk. Results did not vary by sex or anatomic subsite (cardia versus non-cardia). All 13 botanical subgroups examined had no significant associations with either anatomic sub-site. CONCLUSION: We did not observe significant associations between overall fruit and vegetable intake and gastric cancer risk in this large prospective cohort study.
Authors: Lucy Sun; Amy F Subar; Claire Bosire; Sanford M Dawsey; Lisa L Kahle; Thea P Zimmerman; Christian C Abnet; Ruth Heller; Barry I Graubard; Michael B Cook; Jessica L Petrick Journal: J Nutr Date: 2017-07-19 Impact factor: 4.798
Authors: Tianyi Wang; Hui Cai; Shizuka Sasazuki; Shoichiro Tsugane; Wei Zheng; Eo Rin Cho; Sun Ha Jee; Angelika Michel; Michael Pawlita; Yong-Bing Xiang; Yu-Tang Gao; Xiao-Ou Shu; Wei-Cheng You; Meira Epplein Journal: Int J Cancer Date: 2016-10-31 Impact factor: 7.396
Authors: Wen-Qing Li; Yikyung Park; Jennifer W Wu; Jian-Song Ren; Alisa M Goldstein; Philip R Taylor; Albert R Hollenbeck; Neal D Freedman; Christian C Abnet Journal: Clin Gastroenterol Hepatol Date: 2013-04-13 Impact factor: 11.382