OBJECTIVE: The objective of the study was to evaluate whether maternal tobacco use is associated with an attenuation in fetal birthweight among women with nutritional and uteroplacental constraints. STUDY DESIGN: A population-based retrospective analysis of term (37 weeks or longer) singleton pregnancies delivered in Utah from 1991 to 2001. Birthweight (BW) and percent small for gestational age (SGA) (less than 10% for gestational age) among self-identified smokers and nonsmokers were compared. Adjusted odds ratios (ORs) were calculated to measure the association of maternal smoking with delivery of an SGA infant controlling for potential confounders across maternal strata. RESULTS: Among the 424,912 gestations, 37,076 occurred in self-identified smokers. Mean BW was significantly less and the prevalence of SGA infants was significantly greater in tobacco-exposed infants across all maternal BMI strata (P < .001) as well as pregnancies complicated by diabetes (P < .001) and hypertensive disorders (P < .001). In a multivariable logistic regression model, tobacco exposure remained the significant associative factor for SGA (OR 3.53, 95% confidence interval 2.61 to 4.79) after selecting for the first birth in the study interval (n = 283,916). CONCLUSION: Self-identified tobacco use increases the risk of a SGA infant at term across maternal strata.
OBJECTIVE: The objective of the study was to evaluate whether maternal tobacco use is associated with an attenuation in fetal birthweight among women with nutritional and uteroplacental constraints. STUDY DESIGN: A population-based retrospective analysis of term (37 weeks or longer) singleton pregnancies delivered in Utah from 1991 to 2001. Birthweight (BW) and percent small for gestational age (SGA) (less than 10% for gestational age) among self-identified smokers and nonsmokers were compared. Adjusted odds ratios (ORs) were calculated to measure the association of maternal smoking with delivery of an SGA infant controlling for potential confounders across maternal strata. RESULTS: Among the 424,912 gestations, 37,076 occurred in self-identified smokers. Mean BW was significantly less and the prevalence of SGA infants was significantly greater in tobacco-exposed infants across all maternal BMI strata (P < .001) as well as pregnancies complicated by diabetes (P < .001) and hypertensive disorders (P < .001). In a multivariable logistic regression model, tobacco exposure remained the significant associative factor for SGA (OR 3.53, 95% confidence interval 2.61 to 4.79) after selecting for the first birth in the study interval (n = 283,916). CONCLUSION: Self-identified tobacco use increases the risk of a SGA infant at term across maternal strata.
Authors: Kjersti Aagaard-Tillery; Catherine Y Spong; Elizabeth Thom; Baha Sibai; George Wendel; Katharine Wenstrom; Philip Samuels; Hyagriv Simhan; Yoram Sorokin; Menachem Miodovnik; Paul Meis; Mary J O'Sullivan; Deborah Conway; Ronald J Wapner Journal: Obstet Gynecol Date: 2010-03 Impact factor: 7.661
Authors: Melissa Suter; Jun Ma; Alan Harris; Lauren Patterson; Kathleen A Brown; Cynthia Shope; Lori Showalter; Adi Abramovici; Kjersti M Aagaard-Tillery Journal: Epigenetics Date: 2011-11-01 Impact factor: 4.528
Authors: Francesca Pirini; Lynn R Goldman; Ethan Soudry; Rolf U Halden; Frank Witter; David Sidransky; Rafael Guerrero-Preston Journal: Int J Environ Health Res Date: 2017-02 Impact factor: 3.411