OBJECTIVE: The objective of the study was to evaluate the association between folic acid supplementation in early second trimester and the risk of developing preeclampsia. STUDY DESIGN: We carried out a prospective cohort study between October 2002-December 2005. We recruited women who had their prenatal care visit (12-20 weeks' gestation) at the Ottawa Hospital and Kingston General Hospital. All charts for participants with a diagnosis of preeclampsia were audited and blindly adjudicated by 4 study investigators to validate the diagnosis. RESULTS: A total of 2951 pregnant women were included in the final analysis. Supplementation of multivitamins containing folic acid was associated with increased serum folate (on average 10.51 micromol/L), decreased plasma homocysteine (on average 0.39 micromol/L), and reduced risk of preeclampsia (adjusted odds ratio, 0.37; 95% confidence interval, 0.18-0.75). CONCLUSION: Supplementation of multivitamins containing folic acid in the second trimester is associated with reduced risk of preeclampsia.
OBJECTIVE: The objective of the study was to evaluate the association between folic acid supplementation in early second trimester and the risk of developing preeclampsia. STUDY DESIGN: We carried out a prospective cohort study between October 2002-December 2005. We recruited women who had their prenatal care visit (12-20 weeks' gestation) at the Ottawa Hospital and Kingston General Hospital. All charts for participants with a diagnosis of preeclampsia were audited and blindly adjudicated by 4 study investigators to validate the diagnosis. RESULTS: A total of 2951 pregnant women were included in the final analysis. Supplementation of multivitamins containing folic acid was associated with increased serum folate (on average 10.51 micromol/L), decreased plasma homocysteine (on average 0.39 micromol/L), and reduced risk of preeclampsia (adjusted odds ratio, 0.37; 95% confidence interval, 0.18-0.75). CONCLUSION: Supplementation of multivitamins containing folic acid in the second trimester is associated with reduced risk of preeclampsia.
Authors: Cathrine Hoyo; Amy P Murtha; Joellen M Schildkraut; Randy L Jirtle; Wendy Demark-Wahnefried; Michele R Forman; Edwin S Iversen; Joanne Kurtzberg; Francine Overcash; Zhiqing Huang; Susan K Murphy Journal: Epigenetics Date: 2011-07-01 Impact factor: 4.528
Authors: Ahmad A Mousa; Kellie J Archer; Renato Cappello; Guadalupe Estrada-Gutierrez; Christine R Isaacs; Jerome F Strauss; Scott W Walsh Journal: Reprod Sci Date: 2012-08-17 Impact factor: 3.060
Authors: Anna E Beaudin; Cheryll A Perry; Sally P Stabler; Robert H Allen; Patrick J Stover Journal: Am J Clin Nutr Date: 2012-02-29 Impact factor: 7.045
Authors: Y Wang; N Zhao; Q Liu; Y Zhang; J Qiu; X He; M Zhou; H Cui; L Lv; X Lin; C Zhang; H Zhang; R Xu; D Zhu; Y Dang; X Han; H Zhang; H Bai; Y Chen; Z Tang; R Lin; T Yao; J Su; X Xu; X Liu; W Wang; B Ma; S Liu; W Qiu; H Huang; J Liang; S Wang; R A Ehrenkranz; C Kim Journal: Eur J Clin Nutr Date: 2015-01-28 Impact factor: 4.016