OBJECTIVE: This study was undertaken to compare the colposcopic appearance of the cervicovaginal epithelium with spermicide use vs condom use in a low-risk population. STUDY DESIGN: This was an ancillary study of a trial comparing the efficacy of 5 nonoxynol-9 spermicides. A cohort of women who used condoms without spermicide served as a control group. Colposcopic examinations were performed during product use to identify genital lesions. RESULTS:One hundred fifty-one participants had 1 or more follow-up examinations. At baseline, study groups differed only by the prevalence of baseline lesions. New lesions were identified at 49% of follow-up visits. Controlling for the presence of a baseline lesion, compared with condom use none of the spermicides were associated with an increase in new lesions (overall odds ratio, 0.8; 95% CI, 0.4-1.6; P = .5); and lesions characterized by epithelial disruption were less frequent with spermicide use (overall odds ratio, 0.3; 95% CI, 0.1-0.6; P < .001). CONCLUSION: In a low-risk population, women who used nonoxynol-9 spermicides were less likely to have lesions with epithelial disruption, and equally likely to have any new lesion compared with condom use.
RCT Entities:
OBJECTIVE: This study was undertaken to compare the colposcopic appearance of the cervicovaginal epithelium with spermicide use vs condom use in a low-risk population. STUDY DESIGN: This was an ancillary study of a trial comparing the efficacy of 5 nonoxynol-9 spermicides. A cohort of women who used condoms without spermicide served as a control group. Colposcopic examinations were performed during product use to identify genital lesions. RESULTS: One hundred fifty-one participants had 1 or more follow-up examinations. At baseline, study groups differed only by the prevalence of baseline lesions. New lesions were identified at 49% of follow-up visits. Controlling for the presence of a baseline lesion, compared with condom use none of the spermicides were associated with an increase in new lesions (overall odds ratio, 0.8; 95% CI, 0.4-1.6; P = .5); and lesions characterized by epithelial disruption were less frequent with spermicide use (overall odds ratio, 0.3; 95% CI, 0.1-0.6; P < .001). CONCLUSION: In a low-risk population, women who used nonoxynol-9 spermicides were less likely to have lesions with epithelial disruption, and equally likely to have any new lesion compared with condom use.
Authors: Courtney A Schreiber; Leslie A Meyn; Mitchell D Creinin; Kurt T Barnhart; Sharon L Hillier Journal: Obstet Gynecol Date: 2006-01 Impact factor: 7.661
Authors: M K Stafford; H Ward; A Flanagan; I J Rosenstein; D Taylor-Robinson; J R Smith; J Weber; V S Kitchen Journal: J Acquir Immune Defic Syndr Hum Retrovirol Date: 1998-04-01
Authors: P H Kilmarx; K Limpakarnjanarat; S Supawitkul; S Korattana; N L Young; B S Parekh; R A Respess; T D Mastro; M E St Louis Journal: AIDS Date: 1998-05-07 Impact factor: 4.177
Authors: H Irene Su; Courtney A Schreiber; Courtney Fay; Sam Parry; Michal A Elovitz; Jian Zhang; Alka Shaunik; Kurt Barnhart Journal: Contraception Date: 2011-03-29 Impact factor: 3.375
Authors: Lisa C Rohan; Bernard J Moncla; Ratiya Pamela Kunjara Na Ayudhya; Marilyn Cost; Yunda Huang; Fang Gai; Nicole Billitto; J D Lynam; Kara Pryke; Phillip Graebing; Nicole Hopkins; James F Rooney; David Friend; Charlene S Dezzutti Journal: PLoS One Date: 2010-02-19 Impact factor: 3.240