J R Kaiser1, C H Gauss, D K Williams. 1. Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202-3591, USA. kaiserjeffreyr@uams.edu
Abstract
OBJECTIVES: Examining the effects of tracheal suctioning on cerebral hemodynamics of normotensive ventilated very low birth weight (VLBW) infants with normal cranial ultrasounds; determining the factor(s) influencing changes in mean cerebral blood flow velocity (CBFv) after suctioning. METHODS: Seventy-three VLBW infants had continuous monitoring of mean arterial blood pressure (MABP), PaCO(2), PaO(2) and mean CBFv before, during, and after 202 suctioning sessions during the first week of life. Peak (or nadir) and relative changes of the four variables for 45 min after suctioning were calculated. Multiple linear regression was used to determine the factor(s) influencing changes in mean CBFv after suctioning. RESULT: Birth weight was 928+/-244 g; gestational age was 27.0+/-2.0 weeks. Mean CBFv increased to 31.0+/-26.4% after suctioning and remained elevated for 25 min. PaCO(2) was highly associated with mean CBFv (P<0.001), whereas MABP and PaO(2) were not. CONCLUSION: We observed prolonged increases of mean CBFv following suctioning in ventilated VLBW infants that were previously unrecognized. This is concerning since disturbances of CBF may be associated with subsequent brain injury.
OBJECTIVES: Examining the effects of tracheal suctioning on cerebral hemodynamics of normotensive ventilated very low birth weight (VLBW) infants with normal cranial ultrasounds; determining the factor(s) influencing changes in mean cerebral blood flow velocity (CBFv) after suctioning. METHODS: Seventy-three VLBW infants had continuous monitoring of mean arterial blood pressure (MABP), PaCO(2), PaO(2) and mean CBFv before, during, and after 202 suctioning sessions during the first week of life. Peak (or nadir) and relative changes of the four variables for 45 min after suctioning were calculated. Multiple linear regression was used to determine the factor(s) influencing changes in mean CBFv after suctioning. RESULT: Birth weight was 928+/-244 g; gestational age was 27.0+/-2.0 weeks. Mean CBFv increased to 31.0+/-26.4% after suctioning and remained elevated for 25 min. PaCO(2) was highly associated with mean CBFv (P<0.001), whereas MABP and PaO(2) were not. CONCLUSION: We observed prolonged increases of mean CBFv following suctioning in ventilated VLBW infants that were previously unrecognized. This is concerning since disturbances of CBF may be associated with subsequent brain injury.
Authors: Christopher J Rhee; Cristine Sortica da Costa; Topun Austin; Ken M Brady; Marek Czosnyka; Jennifer K Lee Journal: Pediatr Res Date: 2018-09-08 Impact factor: 3.756
Authors: Eun Sun Kim; Jeffrey R Kaiser; Danielle R Rios; Renee A Bornemeier; Christopher J Rhee Journal: Neonatology Date: 2020-05-20 Impact factor: 4.035
Authors: Christopher J Rhee; Jeffrey R Kaiser; Danielle R Rios; Kathleen K Kibler; R Blaine Easley; Dean B Andropoulos; Marek Czosnyka; Peter Smielewski; Georgios V Varsos; Craig G Rusin; C Heath Gauss; D Keith Williams; Ken M Brady Journal: J Pediatr Date: 2016-04-23 Impact factor: 4.406
Authors: Christopher J Rhee; Charles D Fraser; Kathleen Kibler; Ronald B Easley; Dean B Andropoulos; Marek Czosnyka; Georgios V Varsos; Peter Smielewski; Craig G Rusin; Ken M Brady; Jeffrey R Kaiser Journal: Pediatr Res Date: 2015-03-31 Impact factor: 3.756