| Literature DB >> 18164878 |
Margarita Moreno1, Fernando Cañadas, Diana Cardona, Cristina Suñol, Leticia Campa, Maria Carmen Sánchez-Amate, Pilar Flores, Fernando Sanchez-Santed.
Abstract
This study examined the time-course effects (2, 7, 14 and 30 days) of acute chlorpyrifos (CPF) intoxication (250 mg/kg, s.c.) on monoamine systems and acetylcholinesterase (AChE) activity in the striatum and nucleus accumbens of adult male rats. We show that CPF produced significant long-term inhibition of AChE activity in the striatum and nucleus accumbens. In the striatum, CPF intoxication resulted in changes in dopamine (DA) metabolism after 2 days and changes in serotonin (5-HT) turnover after 7 and 15 days. Significant decreases in monoamine content including norepinephrine (NE), DA, 5-HT and their metabolites were found in the nucleus accumbens 30 days after CPF intoxication. These results suggest that acute exposure to CPF induces long-term changes in the monoamine systems (NE, DA and 5-HT) in adult animals. The lack of correlation between regional AChE activity and neurochemical outcomes points to independent mechanisms.Entities:
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Year: 2007 PMID： 18164878 DOI： 10.1016/j.toxlet.2007.11.003
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372