| Literature DB >> 18164606 |
Anshu Rathi1, Arvind Kumar Srivastava, Annie Shirwaikar, Ajay Kumar Singh Rawat, Shanta Mehrotra.
Abstract
The present investigation demonstrates the hepatoprotective potential of 50% ethanolic water extract of whole plant of Fumaria indica and its three fractions viz., hexane, chloroform and butanol against d-galactosamine induced hepatotoxicity in rats. The hepatoprotection was assessed in terms reduction in histological damage, changes in serum enzymes (SGOT, SGPT, ALP) and metabolites bilirubin, reduced glutathione (GSH) and lipid peroxidation (MDA content). Among fractions more than 90% protection was found with butanol fraction in which alkaloid protopine was quantified as highest i.e. about 0.2mg/g by HPTLC. The isolated protopine in doses of 10-20mg p.o. also proved equally effective hepatoprotectants as standard drug silymarine (single dose 25mg p.o.). In general all treatments excluding hexane fraction proved hepatoprotective at par with silymarine (p<or=0.01).Entities:
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Year: 2008 PMID： 18164606 DOI： 10.1016/j.phymed.2007.11.010
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340