OBJECTIVE: To compare goserelin and leuprolide given before hysterectomy for symptomatic large fibroid uteri. METHODS: A randomized study of 66 premenopausal women with fibroid uteri at least 14 weeks of gestation in a gravid uterus. Women were randomized to receive either subcutaneous depot 3.6 mg goserelin or 3.75 mg leuprolide every 4 weeks for a total of 3 doses. Hysterectomy was performed within 1 month of the last dose. RESULTS: A total of 34 women randomized to the goserelin group and 31 women to theleuprolide group were available for analysis. Preoperative hemoglobin level (P=0.89), operative blood loss (P=0.72), and operating time (P=0.39) were not different between the 2 groups. Postoperative hemoglobin was higher in the leuprolide group (P=0.003), but blood transfusion requirement was not different between the groups (P=1.0). Other outcomes and side effects of the drugs were similar. CONCLUSIONS:Goserelin and leuprolide administered before hysterectomy for uterine fibroids have similar perioperative outcomes.
RCT Entities:
OBJECTIVE: To compare goserelin and leuprolide given before hysterectomy for symptomatic large fibroid uteri. METHODS: A randomized study of 66 premenopausal women with fibroid uteri at least 14 weeks of gestation in a gravid uterus. Women were randomized to receive either subcutaneous depot 3.6 mg goserelin or 3.75 mg leuprolide every 4 weeks for a total of 3 doses. Hysterectomy was performed within 1 month of the last dose. RESULTS: A total of 34 women randomized to the goserelin group and 31 women to the leuprolide group were available for analysis. Preoperative hemoglobin level (P=0.89), operative blood loss (P=0.72), and operating time (P=0.39) were not different between the 2 groups. Postoperative hemoglobin was higher in the leuprolide group (P=0.003), but blood transfusion requirement was not different between the groups (P=1.0). Other outcomes and side effects of the drugs were similar. CONCLUSIONS: Goserelin and leuprolide administered before hysterectomy for uterine fibroids have similar perioperative outcomes.
Authors: Elizabeth A Pritts; David J Vanness; Jonathan S Berek; William Parker; Ronald Feinberg; Jacqueline Feinberg; David L Olive Journal: Gynecol Surg Date: 2015-05-19