| Literature DB >> 18164101 |
Garth E Resch1, C Wayne Simpson.
Abstract
Peptide inhibitors of ethanol consumption have shown promise. The purpose of this study was to test the cyclized form of the opioid-derived dipeptide, glycyl-L-glutamine to reduce ethanol consumption after either peripheral injections or site-specific injections into the nucleus accumbens (NAC) of high drinking and low drinking rats. Following I.P. cyclo-glycyl-glutamine (c-GQ), the data show a mean decrease in ethanol intake of 34.4% in P rats, and 39.4% in Sprague-Dawley rats at doses between 5 and 25mg/kg. The data show that peripherally administered c-GQ is effective in reducing ethanol consumption in both high (P) and low (SD) drinking strains of rats and suggests a therapeutic potential.Entities:
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Year: 2007 PMID： 18164101 PMCID： PMC2413149 DOI： 10.1016/j.peptides.2007.11.009
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750