Literature DB >> 18163454

Excessive dopamine neuron loss in progressive supranuclear palsy.

Karen E Murphy1, Tanya Karaconji, Craig D Hardman, Glenda M Halliday.   

Abstract

Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy. (c) 2007 Movement Disorder Society.

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Year:  2008        PMID： 18163454     DOI： 10.1002/mds.21907

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  11 in total

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9.  Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons.

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10.  Unsupervised clustering of dopamine transporter PET imaging discovers heterogeneity of parkinsonism.

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