Literature DB >> 18163127

BRCA1--sowing the seeds crooked in the furrow.

William D Foulkes1.   

Abstract

Breast tumors with deficiency in DNA double-strand break repair might be expected to show aneuploidy. A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers.

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Year:  2008        PMID： 18163127     DOI： 10.1038/ng0108-8

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  7 in total

1.  Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.

Authors:  Chiara Gorrini; Bevan P Gang; Christian Bassi; Andrew Wakeham; Shakiba Pegah Baniasadi; Zhenyue Hao; Wanda Y Li; David W Cescon; Yen-Ting Li; Sam Molyneux; Nadia Penrod; Mathieu Lupien; Edward E Schmidt; Vuk Stambolic; Mona L Gauthier; Tak W Mak
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-24       Impact factor: 11.205

Review 2.  Insights into the Possible Molecular Mechanisms of Resistance to PARP Inhibitors.

Authors:  Claudia Piombino; Laura Cortesi
Journal:  Cancers (Basel)       Date:  2022-06-05       Impact factor: 6.575

Review 3.  Hereditary breast cancer: new genetic developments, new therapeutic avenues.

Authors:  Philippe M Campeau; William D Foulkes; Marc D Tischkowitz
Journal:  Hum Genet       Date:  2008-06-25       Impact factor: 4.132

4.  BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Authors:  Chiara Gorrini; Pegah S Baniasadi; Isaac S Harris; Jennifer Silvester; Satoshi Inoue; Bryan Snow; Purna A Joshi; Andrew Wakeham; Sam D Molyneux; Bernard Martin; Peter Bouwman; David W Cescon; Andrew J Elia; Zoe Winterton-Perks; Jennifer Cruickshank; Dirk Brenner; Alan Tseng; Melinda Musgrave; Hal K Berman; Rama Khokha; Jos Jonkers; Tak W Mak; Mona L Gauthier
Journal:  J Exp Med       Date:  2013-07-15       Impact factor: 14.307

Review 5.  Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair.

Authors:  Akari Minami; Atsuko Nakanishi; Yasunori Ogura; Yasuko Kitagishi; Satoru Matsuda
Journal:  Front Oncol       Date:  2014-11-10       Impact factor: 6.244

6.  Identifying Transcripts with Tandem Duplications from RNA-Sequencing Data to Predict BRCA1-Type Primary Breast Cancer.

Authors:  Shuoying Qu; John W M Martens; Antoinette Hollestelle; Marcel Smid
Journal:  Cancers (Basel)       Date:  2022-01-31       Impact factor: 6.639

7.  The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer.

Authors:  P de Graeff; A P G Crijns; K A Ten Hoor; H G Klip; H Hollema; K Oien; J M Bartlett; G B A Wisman; G H de Bock; E G E de Vries; S de Jong; A G J van der Zee
Journal:  Br J Cancer       Date:  2008-07-22       Impact factor: 7.640
  7 in total

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