Literature DB >> 18161982

A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.

Dexuan Xiang1, Kewei Wang, Yongjiu Liang, Guangyuan Zhou, Dewen Dong.   

Abstract

A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.

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Year:  2007        PMID： 18161982     DOI： 10.1021/ol702846t

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Crystal structure of pirfenidone (5-methyl-1-phenyl-1H-pyridin-2-one): an active pharmaceutical ingredient (API).

Authors:  Mauro Barbero; Matteo Mossotti; Angelo Sironi; Giovanni Battista Giovenzana; Valentina Colombo
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-06-11

2.  An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide.

Authors:  Liquan Tan; Peng Zhou; Cui Chen; Weibing Liu
Journal:  Beilstein J Org Chem       Date:  2013-11-28       Impact factor: 2.883
  2 in total

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