Literature DB >> 18161633

Investigation of serrated roll surface differences on ribbon thickness during roller compaction.

Patrick D Daugherity1, Jennifer H Chu.   

Abstract

Many parameters are considered when developing a roller compaction process. However, roll serration volume is generally not considered when using serrated rolls. It was hypothesized that serration volume of concavo-convex rolls can have a significant effect on ribbon thickness due to differences in nip angle. Experiments were conducted to investigate ribbon thickness using different roll sets having a range of serration volumes. Roll sets with approximately twice the serration volume produce ribbons 20-25% greater in thickness. These results correlated with physical measurements taken of the serrations from each set. Thus, differences in roll serration volume can significantly affect ribbon thickness.

Mesh:

Substances:

Year:  2007        PMID: 18161633     DOI: 10.1080/10837450701563012

Source DB:  PubMed          Journal:  Pharm Dev Technol        ISSN: 1083-7450            Impact factor:   3.133


  2 in total

1.  Quality-by-design III: application of near-infrared spectroscopy to monitor roller compaction in-process and product quality attributes of immediate release tablets.

Authors:  Ravikanth Kona; Raafat M Fahmy; Gregg Claycamp; James E Polli; Marilyn Martinez; Stephen W Hoag
Journal:  AAPS PharmSciTech       Date:  2014-10-16       Impact factor: 3.246

2.  Application of near-infrared spectroscopy in real-time monitoring of product attributes of ribbed roller compacted flakes.

Authors:  Asim Kumar Samanta; Atul D Karande; Ka Yun Ng; Paul Wan Sia Heng
Journal:  AAPS PharmSciTech       Date:  2012-12-11       Impact factor: 3.246

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.