| Literature DB >> 18161576 |
Eun-Kee Park1, Sally K Mak, Dietmar Kültz, Bruce D Hammock.
Abstract
The present study investigates renal inner medullary collecting duct (mIMCD3) cells and human embryonic kidney cells (HEK293) for evaluation of cytotoxicity of nephrotoxic compounds. The 24 h LC(50) values for cisplatin, paraquat and ibuprofen in mIMCD3 cells were 135, 155 and 3600 microM, respectively. The 24 h LC(50) values for paraquat and ibuprofen in HEK293 cells were 180 and 1000 microM, respectively. Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat.Entities:
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Year: 2008 PMID： 18161576 DOI： 10.1080/03601230701735110
Source DB: PubMed Journal: J Environ Sci Health B ISSN： 0360-1234 Impact factor: 1.990