Ynte M Ruigrok1, Rim Elias, Cisca Wijmenga, Gabriël J E Rinkel. 1. Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. ij.m.ruigrok@umcutrecht.nl
Abstract
BACKGROUND: Genetic factors are likely to be involved in the pathogenesis of intracranial, ascending thoracic aorta, and infrarenal aortic abdominal aneurysms. Common genetic risk factors for these three types of aneurysms have been suggested. This review describes the results of whole-genome linkage studies on intracranial, thoracic aorta, and aortic abdominal aneurysms, and compares the genomic loci identified in these studies in search of possible common genetic risk factors for the three aneurysmal types. METHODS: A literature search of all whole-genome linkage studies performed on intracranial, thoracic aorta, and aortic abdominal aneurysms was performed. The genomic loci identified in these studies were described and compared in search of similarities between them. RESULTS: Five chromosomal regions on 3p24-25, 4q32-34, 5q, 11q24, and 19q that may play a role in the pathogenesis of two or more aneurysmal types were identified: 3p24-25 for thoracic aorta and intracranial aneurysms; 4q32-34 for aortic abdominal and intracranial aneurysms; 5q for thoracic aorta and intracranial aneurysms; 11q24 for thoracic aorta, aortic abdominal, and intracranial aneurysms; and 19q for aortic abdominal and intracranial aneurysms. CONCLUSIONS: Five chromosomal regions that may include common genetic factors for intracranial, thoracic aorta, and aortic abdominal aneurysms were identified. Further studies are needed to explore these chromosomal regions in different aneurysm patient groups and may further help to unravel the disease pathogenesis of aneurysms in general.
BACKGROUND: Genetic factors are likely to be involved in the pathogenesis of intracranial, ascending thoracic aorta, and infrarenal aortic abdominal aneurysms. Common genetic risk factors for these three types of aneurysms have been suggested. This review describes the results of whole-genome linkage studies on intracranial, thoracic aorta, and aortic abdominal aneurysms, and compares the genomic loci identified in these studies in search of possible common genetic risk factors for the three aneurysmal types. METHODS: A literature search of all whole-genome linkage studies performed on intracranial, thoracic aorta, and aortic abdominal aneurysms was performed. The genomic loci identified in these studies were described and compared in search of similarities between them. RESULTS: Five chromosomal regions on 3p24-25, 4q32-34, 5q, 11q24, and 19q that may play a role in the pathogenesis of two or more aneurysmal types were identified: 3p24-25 for thoracic aorta and intracranial aneurysms; 4q32-34 for aortic abdominal and intracranial aneurysms; 5q for thoracic aorta and intracranial aneurysms; 11q24 for thoracic aorta, aortic abdominal, and intracranial aneurysms; and 19q for aortic abdominal and intracranial aneurysms. CONCLUSIONS: Five chromosomal regions that may include common genetic factors for intracranial, thoracic aorta, and aortic abdominal aneurysms were identified. Further studies are needed to explore these chromosomal regions in different aneurysmpatient groups and may further help to unravel the disease pathogenesis of aneurysms in general.
Authors: Bradford B Worrall; Tatiana Foroud; Robert D Brown; E Sander Connolly; Richard W Hornung; John Huston; Dawn Kleindorfer; Daniel L Koller; Dongbing Lai; Charles J Moomaw; Laura Sauerbeck; Daniel Woo; Joseph P Broderick Journal: Stroke Date: 2008-10-23 Impact factor: 7.914
Authors: Susanna S Wang; Lisa J Martin; Eric E Schadt; Haijin Meng; Xuping Wang; Wei Zhao; Leslie Ingram-Drake; Martina Nebohacova; Margarete Mehrabian; Thomas A Drake; Aldons J Lusis Journal: Circ Cardiovasc Genet Date: 2009-10-19
Authors: Femke N G van 't Hof; Ynte M Ruigrok; Cue Hyunkyu Lee; Stephan Ripke; Graig Anderson; Mariza de Andrade; Annette F Baas; Jan D Blankensteijn; Erwin P Böttinger; Matthew J Bown; Joseph Broderick; Philippe Bijlenga; David S Carrell; Dana C Crawford; David R Crosslin; Christian Ebeling; Johan G Eriksson; Myriam Fornage; Tatiana Foroud; Mikael von Und Zu Fraunberg; Christoph M Friedrich; Emília I Gaál; Omri Gottesman; Dong-Chuan Guo; Seamus C Harrison; Juha Hernesniemi; Albert Hofman; Ituro Inoue; Juha E Jääskeläinen; Gregory T Jones; Lambertus A L M Kiemeney; Riku Kivisaari; Nerissa Ko; Seppo Koskinen; Michiaki Kubo; Iftikhar J Kullo; Helena Kuivaniemi; Mitja I Kurki; Aki Laakso; Dongbing Lai; Suzanne M Leal; Hanna Lehto; Scott A LeMaire; Siew-Kee Low; Jennifer Malinowski; Catherine A McCarty; Dianna M Milewicz; Thomas H Mosley; Yusuke Nakamura; Hirofumi Nakaoka; Mika Niemelä; Jennifer Pacheco; Peggy L Peissig; Joanna Pera; Laura Rasmussen-Torvik; Marylyn D Ritchie; Fernando Rivadeneira; Andre M van Rij; Regie Lyn P Santos-Cortez; Athanasios Saratzis; Agnieszka Slowik; Atsushi Takahashi; Gerard Tromp; André G Uitterlinden; Shefali S Verma; Sita H Vermeulen; Gao T Wang; Buhm Han; Gabriël J E Rinkel; Paul I W de Bakker Journal: J Am Heart Assoc Date: 2016-07-14 Impact factor: 5.501
Authors: V E C Pourier; C J H C M van Laarhoven; M D I Vergouwen; G J E Rinkel; Gert J de Borst Journal: PLoS One Date: 2017-11-13 Impact factor: 3.240