Literature DB >> 1815975

Digitalis enhances exercise-induced hyperkalaemia.

A Nørgaard1, H E Bøtker, N A Klitgaard, P Toft.   

Abstract

In 9 patients with atrial fibrillation the effect of zero, low and high levels of serum digoxin on exercise-induced hyperkalemia was assessed by bicycle exercise tests. Exercise at each level of serum digoxin was associated with a significant (up to 20%) rise in plasma potassium. At a work load of 75 W the highest level of serum digoxin was associated with a significantly higher maximum plasma potassium concentration as compared to the maximum valueatazero serum digoxin. The enhancement of exercise-induced hyperkalemia may add to the arrhythmogenic effect of digitalis.

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Year:  1991        PMID： 1815975     DOI： 10.1007/BF00314994

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  11 in total

Review 1.  ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE.

Authors:  J C SKOU
Journal:  Physiol Rev       Date:  1965-07       Impact factor: 37.312

2.  Influence of physical exercise on serum digoxin concentration and heart rate in patients with atrial fibrillation.

Authors:  H E Bøtker; P Toft; N A Klitgaard; E E Simonsen
Journal:  Br Heart J       Date:  1991-06

Review 3.  Quantification of the Na,K-pumps in mammalian skeletal muscle.

Authors:  A Nørgaard
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1986

4.  Exercise-induced hyperkalaemia can be reduced in human subjects by moderate training without change in skeletal muscle Na,K-ATPase concentration.

Authors:  K Kjeldsen; A Nørgaard; C Hau
Journal:  Eur J Clin Invest       Date:  1990-12       Impact factor: 4.686

5.  Effect of salbutamol on digoxin concentration in serum and skeletal muscle.

Authors:  M Edner; T Jogestrand
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

Review 6.  Digitalis. Mechanisms of action and clinical use.

Authors:  T W Smith
Journal:  N Engl J Med       Date:  1988-02-11       Impact factor: 91.245

7.  Response to exercise after bed rest and after training.

Authors:  B Saltin; G Blomqvist; J H Mitchell; R L Johnson; K Wildenthal; C B Chapman
Journal:  Circulation       Date:  1968-11       Impact factor: 29.690

8.  Physical exercise and binding of digoxin to skeletal muscle--effect of muscle activation frequency.

Authors:  T Joreteg; T Jogestrand
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

9.  Increased therapeutic range, merely a pharmacokinetic problem?

Authors:  K Kochsiek
Journal:  Basic Res Cardiol       Date:  1984       Impact factor: 17.165

10.  The cardiac glycoside-receptor system in the human heart.

Authors:  E Erdmann; L Brown
Journal:  Eur Heart J       Date:  1983-01       Impact factor: 29.983
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  3 in total

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Authors:  A Grove; B J Lipworth
Journal:  Thorax       Date:  1996-01       Impact factor: 9.139

2.  Expression of the beta 2 adrenoceptor partial agonist/antagonist activity of salbutamol in states of low and high adrenergic tone.

Authors:  A Grove; L C McFarlane; B J Lipworth
Journal:  Thorax       Date:  1995-02       Impact factor: 9.139

3.  Oral digoxin effects on exercise performance, K+ regulation and skeletal muscle Na+ ,K+ -ATPase in healthy humans.

Authors:  Simon Sostaric; Aaron C Petersen; Craig A Goodman; Xiaofei Gong; Tai-Juan Aw; Malcolm J Brown; Andrew Garnham; Collene H Steward; Kate T Murphy; Kate A Carey; James Leppik; Steve F Fraser; David Cameron-Smith; Henry Krum; Rodney J Snow; Michael J McKenna
Journal:  J Physiol       Date:  2022-08-02       Impact factor: 6.228
  3 in total

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