Literature DB >> 181594

Mechanisms of infection with Epstein-Barr virus. I. Viral DNA replication and formation of noninfectious virus particles in superinfected Raji cells.

Y Yajima, M Nonoyama.   

Abstract

Human lymphoblastoid Raji cells, which do not produce virus, supported replication of Epstein-Barr virus (EBV) upon superinfection. Early antigen, viral capsid antigen, and virions were produced in Raji cells superinfected with EBV. Viral DNA replicated under complete inhibition of host cell DNA synthesis to the extent that a few micrograms of EBV DNA were recovered from 107 superinfected Raji cells, corresponding to 5,000 viral genomes/cell. Homology of the synthesized viral DNA to parental EBV DNA was more than 90%. Virions produced by the Raji cells contained a 55S DNA but failed to induce early antigen, viral capsid antigen, and viral DNA synthesis after a second superinfection of Raji cells.

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Year:  1976        PMID： 181594      PMCID： PMC354846     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  15 in total

1.  Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups.

Authors:  W Henle; G Henle; H C Ho; P Burtin; Y Cachin; P Clifford; A de Schryver; G de-Thé; V Diehl; G Klein
Journal:  J Natl Cancer Inst       Date:  1970-01       Impact factor: 13.506

2.  VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA.

Authors:  M A EPSTEIN; B G ACHONG; Y M BARR
Journal:  Lancet       Date:  1964-03-28       Impact factor: 79.321

3.  DNA of Epstein-Barr virus. I. Comparative studies of the DNA of Epstein-Barr virus from HR-1 and B95-8 cells: size, structure, and relatedness.

Authors:  R F Pritchett; S D Hayward; E D Kieff
Journal:  J Virol       Date:  1975-03       Impact factor: 5.103

4.  Replication of viral deoxyribonucleic acid and breakdown of cellular deoxyribonucleic acid in Epstein-Barr virus infection.

Authors:  M Nonoyama; J S Pagano
Journal:  J Virol       Date:  1972-04       Impact factor: 5.103

5.  Appearance of Epstein-Barr virus-associated antigens in infected Raji cells.

Authors:  L Gergely; G Klein; I Ernberg
Journal:  Virology       Date:  1971-07       Impact factor: 3.616

6.  Detection of Epstein-Barr viral genome in nonproductive cells.

Authors:  M Nonoyama; J S Pagano
Journal:  Nat New Biol       Date:  1971-09-22

7.  Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.

Authors:  G Klein; L Dombos; B Gothoskar
Journal:  Int J Cancer       Date:  1972-07-15       Impact factor: 7.396

8.  Release of infectious Epstein-Barr virus by transformed marmoset leukocytes.

Authors:  G Miller; M Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1973-01       Impact factor: 11.205

9.  Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2.

Authors:  E D Kieff; S L Bachenheimer; B Roizman
Journal:  J Virol       Date:  1971-08       Impact factor: 5.103

10.  Differential reactivity of human serums with early antigens induced by Epstein-Barr virus.

Authors:  W Henle; G Henle; B A Zajac; G Pearson; R Waubke; M Scriba
Journal:  Science       Date:  1970-07-10       Impact factor: 47.728
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  13 in total

1.  Activation of endogenous type C virus in BALB/c mouse cells by herpesvirus DNA.

Authors:  A L Boyd; J G Derge; B Hampar
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  The Epstein-Barr virus alkaline exonuclease BGLF5 serves pleiotropic functions in virus replication.

Authors:  R Feederle; H Bannert; H Lips; N Müller-Lantzsch; H-J Delecluse
Journal:  J Virol       Date:  2009-03-04       Impact factor: 5.103

3.  Epstein-barr virus-specific RNA. II. Analysis of polyadenylated viral RNA in restringent, abortive, and prooductive infections.

Authors:  T Orellana; E Kieff
Journal:  J Virol       Date:  1977-05       Impact factor: 5.103

4.  Transforming activity of Epstein-Barr virus obtained by superinfection of Raji cells.

Authors:  Y Yajima; B Marczynska; M Nonoyama
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

5.  Replication of Epstein-Barr virus: ultrastructural and immunofluorescent studies of P3HR1-superinfected Raji cells.

Authors:  J M Seigneurin; M Vuillaume; G Lenoir; G De-Thé
Journal:  J Virol       Date:  1977-12       Impact factor: 5.103

6.  Nucleosomal structure of Epstein-Barr virus DNA in transformed cell lines.

Authors:  J E Shaw; L F Levinger; C W Carter
Journal:  J Virol       Date:  1979-02       Impact factor: 5.103

7.  Sedimentation characteristics of newly synthesized Epstein-Barr viral DNA in superinfected cells.

Authors:  P J Siegel; W Clough; J L Strominger
Journal:  J Virol       Date:  1981-06       Impact factor: 5.103

8.  Epstein-Barr virus polypeptides: effect of inhibition of viral DNA replication on their synthesis.

Authors:  R J Feighny; B E Henry; J S Pagano
Journal:  J Virol       Date:  1981-01       Impact factor: 5.103

9.  Mapping of genes in BamHI fragment M of Epstein-Barr virus DNA that may determine the fate of viral infection.

Authors:  J Sample; G Lancz; M Nonoyama
Journal:  J Virol       Date:  1986-01       Impact factor: 5.103

10.  Structure of defective DNA molecules in Epstein-Barr virus preparations from P3HR-1 cells.

Authors:  M S Cho; G W Bornkamm; H zur Hausen
Journal:  J Virol       Date:  1984-07       Impact factor: 5.103
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