OBJECTIVE: To evaluate whether resistance to HIV-1 infection in a subset of highly exposed sex workers correlates with resistance at the cellular level. DESIGN: In vitro evaluation of susceptibility to infection by Kenyan HIV-1 isolates and cellular production of potential mediators of resistance. SETTING: Samples were collected in a primary care clinic in Nairobi. PATIENTS: Thirteen individuals from a cohort of sex workers with a similar risk of acquiring HIV infection and six unexposed controls. INTERVENTIONS: Subjects were provided with appropriate primary care and counselling on the prevention of sexually transmitted diseases. RESULTS: No inherent cellular resistance to infection was identified. CD8⁺ cells from a subset of subjects strongly inhibited viral replication. CONCLUSIONS: Lack of infection in this cohort was not attributable to factors inherent to CD4⁺ cells. Resistance to HIV infection is likely to be multifactorial, and products of CD8⁺ cells and unique features of mucosal sites probably contribute to this state.
OBJECTIVE: To evaluate whether resistance to HIV-1 infection in a subset of highly exposed sex workers correlates with resistance at the cellular level. DESIGN: In vitro evaluation of susceptibility to infection by Kenyan HIV-1 isolates and cellular production of potential mediators of resistance. SETTING: Samples were collected in a primary care clinic in Nairobi. PATIENTS: Thirteen individuals from a cohort of sex workers with a similar risk of acquiring HIV infection and six unexposed controls. INTERVENTIONS: Subjects were provided with appropriate primary care and counselling on the prevention of sexually transmitted diseases. RESULTS: No inherent cellular resistance to infection was identified. CD8⁺ cells from a subset of subjects strongly inhibited viral replication. CONCLUSIONS: Lack of infection in this cohort was not attributable to factors inherent to CD4⁺ cells. Resistance to HIV infection is likely to be multifactorial, and products of CD8⁺ cells and unique features of mucosal sites probably contribute to this state.
Entities:
Keywords:
CD8 cell-mediated suppression; HIV; HIV resistance; Sex workers
Authors: K R Fowke; N J Nagelkerke; J Kimani; J N Simonsen; A O Anzala; J J Bwayo; K S MacDonald; E N Ngugi; F A Plummer Journal: Lancet Date: 1996-11-16 Impact factor: 79.321
Authors: S L Rowland-Jones; D F Nixon; M C Aldhous; F Gotch; K Ariyoshi; N Hallam; J S Kroll; K Froebel; A McMichael Journal: Lancet Date: 1993-04-03 Impact factor: 79.321
Authors: M Clerici; J V Giorgi; C C Chou; V K Gudeman; J A Zack; P Gupta; H N Ho; P G Nishanian; J A Berzofsky; G M Shearer Journal: J Infect Dis Date: 1992-06 Impact factor: 5.226
Authors: W A Paxton; S R Martin; D Tse; T R O'Brien; J Skurnick; N L VanDevanter; N Padian; J F Braun; D P Kotler; S M Wolinsky; R A Koup Journal: Nat Med Date: 1996-04 Impact factor: 53.440
Authors: S Rowland-Jones; J Sutton; K Ariyoshi; T Dong; F Gotch; S McAdam; D Whitby; S Sabally; A Gallimore; T Corrah Journal: Nat Med Date: 1995-01 Impact factor: 53.440
Authors: A Beretta; S H Weiss; G Rappocciolo; R Mayur; C De Santis; J Quirinale; A Cosma; P Robbioni; G M Shearer; J A Berzofsky Journal: J Infect Dis Date: 1996-02 Impact factor: 5.226
Authors: M Dean; M Carrington; C Winkler; G A Huttley; M W Smith; R Allikmets; J J Goedert; S P Buchbinder; E Vittinghoff; E Gomperts; S Donfield; D Vlahov; R Kaslow; A Saah; C Rinaldo; R Detels; S J O'Brien Journal: Science Date: 1996-09-27 Impact factor: 47.728
Authors: L A Pinto; J Sullivan; J A Berzofsky; M Clerici; H A Kessler; A L Landay; G M Shearer Journal: J Clin Invest Date: 1995-08 Impact factor: 14.808